CAS 187523-35-9

BMS 204352

Description:

BMS 204352, with the CAS number 187523-35-9, is a chemical compound that has been studied primarily for its potential therapeutic applications. It is classified as a small molecule and is known to act as a selective inhibitor of certain biological pathways, particularly those involved in cancer cell proliferation and survival. The compound exhibits a specific mechanism of action that targets particular enzymes or receptors, making it a candidate for research in oncology. Its chemical structure includes functional groups that contribute to its biological activity and solubility properties. In preclinical studies, BMS 204352 has shown promise in inhibiting tumor growth and may have implications for the development of targeted cancer therapies. However, detailed pharmacokinetic and toxicological profiles are essential for understanding its safety and efficacy in clinical settings. As with many investigational compounds, ongoing research is necessary to fully elucidate its characteristics and potential applications in medicine.

Formula: C₁₆H₁₀ClF₄NO₂

InChI: InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1

InChI key: InChIKey=ULYONBAOIMCNEH-HNNXBMFYSA-N

SMILES: F[C@@]1(C=2C(NC1=O)=CC(C(F)(F)F)=CC2)C3=C(OC)C=CC(Cl)=C3

Synonyms:

• (3R)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one
• (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one
• (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one
• (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-2,3-dihydro-1H-indol-2-one
• (S)-3-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one
• 2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-
• 2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (S)-
• Bms-204352
• Flindokalner
• Flindokalner [USAN:INN]
• MaxiPost

Flindokalner

CAS: 187523-35-9

Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.

Formula: C₁₆H₁₀ClF₄NO₂

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 359.7

Ref: TM-T15286

(S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one

CAS: 187523-35-9

Formula: C₁₆H₁₀ClF₄NO₂

Purity: 99%

Molecular weight: 359.7027

Ref: IN-DA007RXB

Flindokalner

CAS: 187523-35-9

Flindokalner

Purity: ≥98%

Molecular weight: 359.7g/mol

Ref: 54-BUP08704

BMS 204352

Controlled Product

CAS: 187523-35-9

Applications BMS 204352 is a potassium channel opener that can be used to treat stroke.
References Jensen, S. B.: CNS Drug. Rev. 8, 353 (2002); Gribkoff, V. K., et al.: Nat Med 7, 471 (2001)

Formula: C₁₆H₁₀ClF₄NO₂

Color and Shape: Neat

Molecular weight: 359.703

Ref: TR-B596030