CAS 187669-62-1

1-[4-(Trifluoromethoxy)phenyl]piperazine

Description:

1-[4-(Trifluoromethoxy)phenyl]piperazine is a chemical compound characterized by its piperazine core, which is a six-membered ring containing two nitrogen atoms. The presence of a trifluoromethoxy group attached to a phenyl ring significantly influences its chemical properties and biological activity. This compound is typically a white to off-white solid and is soluble in organic solvents, reflecting its hydrophobic characteristics due to the trifluoromethoxy substituent. The trifluoromethoxy group enhances the lipophilicity and metabolic stability of the molecule, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting various neurological and psychiatric disorders. Its structure allows for potential interactions with neurotransmitter receptors, which may contribute to its pharmacological effects. As with many piperazine derivatives, it may exhibit a range of biological activities, including anxiolytic or antidepressant effects, although specific activities would depend on further empirical studies. Safety and handling precautions should be observed, as with all chemical substances, due to potential toxicity or reactivity.

Formula: C₁₁H₁₃F₃N₂O

InChI: InChI=1S/C11H13F3N2O/c12-11(13,14)17-10-3-1-9(2-4-10)16-7-5-15-6-8-16/h1-4,15H,5-8H2

InChI key: InChIKey=UWPIAGRNHBMGHQ-UHFFFAOYSA-N

SMILES: O(C(F)(F)F)C1=CC=C(C=C1)N2CCNCC2

Synonyms:

• 1-[4-(Trifluoromethoxy)phenyl]piperazine
• 187669-62-1
• 4-(4-Trifluoromethoxyphenyl)piperazine
• Piperazine, 1-[4-(trifluoromethoxy)phenyl]-
• 1-(4-Trifluoromethoxyphenyl)piperazine