CAS 18771-50-1
:Tetrahydrouridine
Description:
Tetrahydrouridine (THU) is a nucleoside analog that primarily functions as an inhibitor of the enzyme cytidine deaminase, which is involved in the metabolism of nucleosides. Its chemical structure features a pyrimidine ring with a tetrahydrofuran moiety, contributing to its unique properties. THU is known for its ability to enhance the bioavailability of certain nucleoside analogs by preventing their degradation, thus increasing their therapeutic efficacy. It is often studied in the context of antiviral and anticancer therapies, particularly in combination with other nucleoside analogs. THU is typically administered in a pharmaceutical form, and its solubility and stability are important factors in its application. Additionally, it has been investigated for its potential role in modulating immune responses and in various biochemical research applications. Safety and toxicity profiles are essential considerations in its use, and ongoing research continues to explore its full range of biological activities and therapeutic potential.
Formula:C9H16N2O6
InChI:InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
InChI key:InChIKey=UCKYOOZPSJFJIZ-XVKVHKPRSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(O)CC2
Synonyms:- 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone
- 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
- 3,4,5,6-Tetrahydrouridine
- 4-hydroxy-1-(beta-D-ribofuranosyl)tetrahydropyrimidin-2(1H)-one
- 4-hydroxy-1-pentofuranosyltetrahydropyrimidin-2(1H)-one
- 5,6-Dihydrouridine
- Brn 0752319
- Nsc 112907
- Nsc-112907-D
- U 23284
- Uridine, 3,4,5,6-tetrahydro-
- Tetrahydrouridine
- 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-D-ribofuranosyl-
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 6 products.
3,4,5,6-Tetrahydrouridine (>80%)
CAS:<p>Stability Light Sensitive<br>Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.<br>References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);<br></p>Formula:C9H16N2O6Purity:>80%Color and Shape:NeatMolecular weight:248.23Tetrahydrouridine
CAS:<p>Tetrahydrouridine is a pyrimidine nucleoside that has been shown to have inhibitory properties in clinical pathology. Tetrahydrouridine is a natural product derived from the amino acid histidine and is found in the cells of many living organisms. It is believed that tetrahydrouridine may be useful as an adjuvant to radiation therapy, and it has been shown to reduce the toxicity of chemotherapy drugs, such as decitabine and Ara-C. Tetrahydrouridine inhibits enzymes involved in DNA methylation, which can lead to cancer cell death.br><br>Tetrahydrouridine also has inhibitory effects on enzymes that produce cytidine from uracil, which can help prevent the formation of cancerous cells.br><br>Tetrahydrouridine inhibits deaminase activity, which produces uracil from cytosine. This inhibition prevents the production of uracil-cytosine</p>Formula:C9H16N2O6Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:248.23 g/molTetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purity:98%Color and Shape:SolidMolecular weight:248.23
