CAS 187724-61-4

Phenol,4-[4-[[(1R)-1-phenylethyl]amino]-1H-pyrrolo[2,3-d]pyrimidin-6-yl]-

Description:

The chemical substance known as Phenol, 4-[4-[[(1R)-1-phenylethyl]amino]-1H-pyrrolo[2,3-d]pyrimidin-6-yl]- is characterized by its complex molecular structure, which includes a phenolic group and a pyrrolopyrimidine moiety. This compound features a chiral center due to the presence of the (1R)-1-phenylethyl group, which contributes to its stereochemistry and potential biological activity. The presence of the amino group suggests that it may engage in hydrogen bonding, influencing its solubility and reactivity. The compound is likely to exhibit properties typical of both phenolic and heterocyclic compounds, such as antioxidant activity or interactions with biological targets. Its specific applications may include roles in medicinal chemistry, particularly in the development of pharmaceuticals, given its structural features that could interact with biological systems. The CAS number 187724-61-4 uniquely identifies this compound in chemical databases, facilitating its study and application in various scientific fields.

Formula: C₂₀H₁₈N₄O

PKI-166

CAS: 187724-61-4

PKI-166

Purity: ≥98%

Molecular weight: 330.38g/mol

Ref: 54-BUP15283

PKI-166

CAS: 187724-61-4

PKI-166 is a mitochondria-targeted prodrug that has been shown to be cytotoxic in vitro and in vivo. It binds to the mitochondrial membrane and causes depolarization, which leads to apoptosis. PKI-166 has also been shown to inhibit tumor growth in a rat model of subcutaneous tumors. The drug is cell type specific and does not affect normal cells such as fetal bovine or mouse embryonic fibroblasts. PKI-166 is activated by dna binding activity and can bind to DNA as well as proteins such as epidermal growth factor (EGF) and tetrazolium dye. PKI-166 has pharmacokinetic properties that are different from other drugs in its class, which include a long half-life and low clearance rate. The drug also inhibits the proliferation of carcinoma cell lines with high epidermal growth factor receptor expression levels, but not with low EGF receptor expression levels.

Formula: C₂₀H₁₈N₄O

Purity: Min. 95%

Molecular weight: 330.38 g/mol

Ref: 3D-MHA72461

PKI-166

CAS: 187724-61-4

PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.

Formula: C₂₀H₁₈N₄O

Purity: 99.2%

Color and Shape: Solid

Molecular weight: 330.38

Ref: TM-T16549