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CAS 187731-34-6

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(R)-Lercanidipine Hydrochloride

Description:
(R)-Lercanidipine Hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to selectively inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent reduction in blood pressure. The compound is a chiral molecule, with the (R)-enantiomer being the active form that exhibits greater pharmacological activity. Lercanidipine is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. It is typically administered in the form of hydrochloride salt, which improves its solubility and bioavailability. Common side effects may include peripheral edema, headache, and gastrointestinal disturbances. As with other calcium channel blockers, caution is advised in patients with heart failure or significant aortic stenosis. Overall, (R)-Lercanidipine Hydrochloride is an effective antihypertensive agent with a favorable pharmacokinetic profile.
Formula:C36H42ClN3O6
InChI:InChI=1/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H/t33-;/m1./s1
SMILES:CC1=C([C@@H](c2cccc(c2)N(=O)=O)C(=C(C)N1)C(=O)OC(C)(C)CN(C)CCC(c1ccccc1)c1ccccc1)C(=O)OC.Cl
Synonyms:
  • (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
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