CAS 1879-77-2

doxibetasol

Description:

Doxibetasol, with the CAS number 1879-77-2, is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its potent glucocorticoid activity, which makes it effective in treating various dermatological conditions, such as psoriasis and eczema. Doxibetasol exhibits a high affinity for glucocorticoid receptors, leading to a reduction in inflammation and modulation of immune responses. The substance is typically formulated as a topical ointment or cream, allowing for localized treatment with minimal systemic absorption. Its chemical structure includes a steroid backbone, which is essential for its biological activity. Doxibetasol is known for its relatively low side effect profile when used appropriately, although prolonged use can lead to skin atrophy and other local effects. As with other corticosteroids, it is important to use doxibetasol under medical supervision to ensure safety and efficacy in treatment.

Formula: C₂₂H₂₉FO₄

InChI: InChI=1/C22H29FO4/c1-12-9-17-16-6-5-14-10-15(25)7-8-19(14,3)21(16,23)18(26)11-20(17,4)22(12,27)13(2)24/h7-8,10,12,16-18,26-27H,5-6,9,11H2,1-4H3/t12-,16-,17-,18-,19-,20-,21-,22-/m0/s1

InChI key: InChIKey=IKGBPSZWCRRUQS-DTAAKRQUSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(C)=O)(O)[C@@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (11Beta,16Beta)-9-Fluoro-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (11β,16β)-9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 21-Deoxybetamethasone
• 9-Fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
• 9-Fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
• Doxibetasol [INN]
• Doxibetasolum
• Doxibetasolum [INN-Latin]
• Doxybetasol
• Gr 2/443
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-16β-methyl-
• Unii-0Js043Fg0D
• Doxibetasol
• Doxibetasol
• 9-Fluoro-16-methylpregna-1,4-diene-11,17-diol-3,20-dione
• Betamethasone Valerate impurity 1/Betamethasone Valerate EP Impurity B/Doxybetasol/21-Deoxy Betamethasone
• (8S,9R,10S,11S,13S,14S,16S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• Betamethasone Valerate EP Impurity B
• 9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• (8S,9R,10S,11S,13S,14S,16S,17R)-17-ethanoyl-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• 16β-methyl-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione
• 21-Deoxy Betamethasone

(11β,16β)-9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

CAS: 1879-77-2

Formula: C₂₂H₂₉FO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 376.4617

Ref: IN-DA002GK4

Betamethasone Valerate EP Impurity B (21-Deoxy Betamethasone)

CAS: 1879-77-2

Formula: C₂₂H₂₉FO₄

Color and Shape: Pale Yellow Solid

Molecular weight: 376.47

Ref: 4Z-B-065031

Doxybetasol

Controlled Product

CAS: 1879-77-2

Impurity Betamethasone Valerate EP Impurity B
Applications Doxybetasol (Betamethasone Valerate EP Impurity B) is an impurity of Betamethasone (B327000), which is a glucocorticoid used as an anti-inflammatory agent.
References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006),

Formula: C₂₂H₂₉FO₄

Color and Shape: Neat

Molecular weight: 376.46

Ref: TR-D561000

Betamethasone Valerate EP Impurity B

CAS: 1879-77-2

Formula: C₂₂H₂₉FO₄

Molecular weight: 376.47

Ref: ST-EA-CP-B5002