CAS 187949-02-6

Albaconazole

Description:

Albaconazole is an antifungal agent belonging to the triazole class, primarily used in the treatment of various fungal infections. It exhibits a broad spectrum of activity against a range of fungi, including dermatophytes and yeasts. The compound functions by inhibiting the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis in fungal cell membranes, ultimately leading to cell death. Albaconazole is characterized by its lipophilic nature, which enhances its ability to penetrate fungal cells. It is typically administered orally and has a favorable pharmacokinetic profile, including good bioavailability and tissue distribution. The substance is also noted for its relatively low toxicity in comparison to other antifungal agents, making it a suitable option for treating systemic fungal infections. Additionally, ongoing research is exploring its efficacy against resistant fungal strains, highlighting its potential role in modern antifungal therapy. As with any medication, the use of albaconazole should be guided by a healthcare professional, considering potential side effects and interactions with other drugs.

Formula: C₂₀H₁₆ClF₂N₅O₂

InChI: InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1

InChI key: InChIKey=UHIXWHUVLCAJQL-MPBGBICISA-N

SMILES: [C@@]([C@@H](C)N1C(=O)C=2C(N=C1)=CC(Cl)=CC2)(CN3C=NC=N3)(O)C4=C(F)C=C(F)C=C4

Synonyms:

• (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
• 4(3H)-Quinazolinone, 7-chloro-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-
• 4(3H)-Quinazolinone, 7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-, [R-(R*,R*)]-
• 7-Chloro-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4(3H)-quinazolinone
• 7-chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4(3H)-one
• Ur 9625
• Ur-9825

4(3H)-Quinazolinone, 7-chloro-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-

CAS: 187949-02-6

Formula: C₂₀H₁₆ClF₂N₅O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 431.8231

Ref: IN-DA002GL9

Albaconazole

CAS: 187949-02-6

Albaconazole

Purity: ≥98%

Molecular weight: 431.82g/mol

Ref: 54-BUP07547

Albaconazole

CAS: 187949-02-6

Formula: C₂₀H₁₆ClF₂N₅O₂

Molecular weight: 431.83

Ref: 4Z-A-423001

Albaconazole

CAS: 187949-02-6

Formula: C₂₀H₁₆ClF₂N₅O₂

Color and Shape: White To Light Yellow

Molecular weight: 431.82

Ref: TR-A511450

Albaconazole

CAS: 187949-02-6

Albaconazole, a small fungal CYP51A1 inhibitor, treats fungal infections and some musculoskeletal disorders.

Formula: C₂₀H₁₆ClF₂N₅O₂

Purity: 99.27%

Color and Shape: Solid

Molecular weight: 431.82

Ref: TM-T7725