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CAS 187949-02-6

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Albaconazole

Description:
Albaconazole is an antifungal agent belonging to the triazole class, primarily used in the treatment of various fungal infections. It exhibits a broad spectrum of activity against a range of fungi, including dermatophytes and yeasts. The compound functions by inhibiting the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis in fungal cell membranes, ultimately leading to cell death. Albaconazole is characterized by its lipophilic nature, which enhances its ability to penetrate fungal cells. It is typically administered orally and has a favorable pharmacokinetic profile, including good bioavailability and tissue distribution. The substance is also noted for its relatively low toxicity in comparison to other antifungal agents, making it a suitable option for treating systemic fungal infections. Additionally, ongoing research is exploring its efficacy against resistant fungal strains, highlighting its potential role in modern antifungal therapy. As with any medication, the use of albaconazole should be guided by a healthcare professional, considering potential side effects and interactions with other drugs.
Formula:C20H16ClF2N5O2
InChI:InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1
InChI key:InChIKey=UHIXWHUVLCAJQL-MPBGBICISA-N
SMILES:[C@@]([C@@H](C)N1C(=O)C=2C(N=C1)=CC(Cl)=CC2)(CN3C=NC=N3)(O)C4=C(F)C=C(F)C=C4
Synonyms:
  • (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
  • 4(3H)-Quinazolinone, 7-chloro-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-
  • 4(3H)-Quinazolinone, 7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-, [R-(R*,R*)]-
  • 7-Chloro-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4(3H)-quinazolinone
  • 7-chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4(3H)-one
  • Ur 9625
  • Ur-9825
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