CAS 187960-08-3

Genistein-D4 (4-Hydroxyphenyl-2,3,5,6-D4)

Description:

Genistein-D4, also known as 4-Hydroxyphenyl-2,3,5,6-D4, is a deuterated form of genistein, a naturally occurring isoflavone predominantly found in soy products. The deuteration at specific positions (2, 3, 5, and 6) enhances its stability and allows for more precise tracking in metabolic studies and pharmacokinetic research. Genistein itself is known for its phytoestrogenic properties, which can mimic estrogen in the body, and has been studied for its potential health benefits, including antioxidant activity, anti-cancer properties, and effects on bone health. The presence of deuterium in Genistein-D4 can improve the accuracy of analytical techniques such as mass spectrometry, making it a valuable tool in biochemical research. This compound is typically used in studies investigating the biological effects of genistein while minimizing the interference from naturally occurring isotopes. As with any chemical substance, handling should be done with care, following appropriate safety protocols.

Genistein-d4 (4-hydroxy-phenyl-2,3,5,6-d4)

CAS: 187960-08-3

Purity: 95 atom % D

Color and Shape: Off-White Solid

Molecular weight: 274.27

Ref: 3U-D6282

Genistein-2’,3’,5’,6’-d4 (Major)

Controlled Product

CAS: 187960-08-3

Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)

Formula: C₁₅₂H₄H₆O₅

Color and Shape: Neat

Molecular weight: 274.26

Ref: TR-G350010

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-

CAS: 187960-08-3

Formula: C₁₅H₆D₄O₅

Purity: 98.81%

Color and Shape: Solid

Molecular weight: 274.2615

Ref: IN-DA002GL6