CAS 1880-61-1

17-OXODEXAMETHASONE

Description:

17-Oxodexamethasone, with the CAS number 1880-61-1, is a synthetic glucocorticoid and a derivative of dexamethasone, which is a potent anti-inflammatory and immunosuppressive agent. This compound is characterized by its steroidal structure, featuring a cyclopentanoperhydrophenanthrene core, which is typical of corticosteroids. It possesses a ketone functional group at the 17-position, which distinguishes it from its parent compound, dexamethasone. 17-Oxodexamethasone exhibits anti-inflammatory properties by inhibiting the release of inflammatory mediators and modulating immune responses. It is often studied for its potential therapeutic applications in conditions such as autoimmune diseases, allergies, and certain types of cancer. The compound is typically administered in various formulations, including oral and injectable forms, and its pharmacokinetics involve metabolism primarily in the liver. As with other glucocorticoids, its use may be associated with side effects, particularly with long-term administration, necessitating careful monitoring and dosage adjustments.

Formula: C₂₀H₂₅FO₃

InChI: InChI=1/C20H25FO3/c1-11-8-15-14-5-4-12-9-13(22)6-7-19(12,3)20(14,21)16(23)10-18(15,2)17(11)24/h6-7,9,11,14-16,23H,4-5,8,10H2,1-3H3

SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(C(CC2(C)C1=O)O)F

Synonyms:

• 9-Fluoro-11b-hydroxy-16a-methyl Androsta-1,4-diene-3,17-dione
• Nsc 50909
• 9-Fluoro-11-hydroxy-16-methyl-(11b,16a ) Androsta-1,4-diene-3,17-dione
• 9alpha-Fluoro-11beta-hydroxy-16alpha-methyl-1,4-androstadiene-3,17-dio ne
• 9-Fluoro-11-hydroxy-16a-methyl Androsta-1,4-diene-3,17-dione
• 9-Fluoro-11-hydroxy-16-methyl-(11,16a ) Androsta-1,4-diene-3,17-dione
• (11Beta,16Alpha)-9-Fluoro-11-Hydroxy-16-Methylandrosta-1,4-Diene-3,17-Dione
• 9-Fluoro-11-Hydroxy-16-Methylandrosta-1,4-Diene-3,17-Dione

17-Oxo Dexamethasone ((8S,9R,10S,11S,13S,14S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione)

CAS: 1880-61-1

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₂₀H₂₅FO₃

Color and Shape: Off-White White Solid

Molecular weight: 332.17877

Ref: 45-1A00470

17-Oxo Dexamethasone

CAS: 1880-61-1

Formula: C₂₀H₂₅FO₃

Color and Shape: Solid

Molecular weight: 332.4091

Ref: IN-DA002GNN

17-Oxo Dexamethasone

CAS: 1880-61-1

Formula: C₂₀H₂₅FO₃

Color and Shape: White To Off-White Solid

Molecular weight: 332.42

Ref: 4Z-D-3642

Dexamethasone-17-ketone (9α-Fluoro-11β-hydroxy-16α-methylandrosta-1,4-diene-3,17-dione)

Controlled Product

CAS: 1880-61-1

Formula: C₂₀H₂₅FO₃

Color and Shape: Neat

Molecular weight: 332.41

Ref: 86-MM0213.10

17-Oxo Dexamethasone

Controlled Product

CAS: 1880-61-1

Formula: C₂₀H₂₅FO₃

Color and Shape: White

Molecular weight: 332.41

Ref: TR-O855200

17-Oxo dexamethasone

Controlled Product

CAS: 1880-61-1

17-Oxo dexamethasone is a mixture of 17-hydroxy-6,7-dihydro-17α-methylpregna-1,4,9(11)-triene-3,20-dione and its 3β,5β stereoisomers. It is an oxidation product of dexamethasone that may be formed during the synthesis or storage of this drug. The impurity has been identified by high resolution mass spectrometry. A potent anti tuberculosis drug belonging to the class of rifamycins Rifapentine inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication. This active form is metabolized through a number of metabolic transformations including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase or conjugation with glucuronic acid. Rifapentine

Formula: C₂₀H₂₅FO₃

Purity: Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 332.41 g/mol

Ref: 3D-FO26646

17-Ketone Dexamethasone

CAS: 1880-61-1

Formula: C₂₀H₂₅FO₃

Molecular weight: 332.42

Ref: ST-EA-CP-D17018