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CAS 188062-50-2

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Abacavir sulfate

Description:
Abacavir sulfate is an antiretroviral medication primarily used in the treatment of HIV infection. It is a nucleoside reverse transcriptase inhibitor (NRTI) that works by interfering with the viral replication process. The compound is characterized by its chemical structure, which includes a bicyclic core and a sulfate moiety, contributing to its pharmacological properties. Abacavir is known for its oral bioavailability and is often administered in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. It is important to note that abacavir can cause hypersensitivity reactions in some individuals, necessitating genetic testing for the HLA-B*5701 allele prior to initiation of therapy. The substance is typically supplied as a sulfate salt to improve solubility and stability. In terms of physical properties, abacavir sulfate is a white to off-white powder, and it is soluble in water, making it suitable for formulation in various dosage forms. Overall, abacavir sulfate plays a crucial role in modern HIV treatment regimens.
Formula:C14H18N6OH2O4S
InChI:InChI=1S/C14H18N6O.H2O4S/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t8-,10+;/m1./s1
InChI key:InChIKey=MBFKCGGQTYQTLR-SCYNACPDSA-N
SMILES:N(C1=C2C(N(C=N2)[C@@H]3C[C@H](CO)C=C3)=NC(N)=N1)C4CC4.S(=O)(=O)(O)O
Synonyms:
  • (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate
  • 1592U89 sulfate
  • 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-, sulfate (2:1)
  • 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-, sulfate (2:1) (salt)
  • 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S-cis)-, sulfate (2:1) (salt)
  • ABC sulfate
  • Abacavir Sulfale
  • Abacavir hemisulfate
  • Abacavir sulphate
  • Abamune
  • See more synonyms
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  • rac-Abacavir Sulfate
    TRC
    + Info

    rac-Abacavir Sulfate

    Controlled Product
    CAS:
    Formula:C14H18N6O·H2SO4
    Color and Shape:Neat
    Molecular weight:670.743

    Ref: TR-A105025

    500mg
    12,795.00€