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CAS 1881-07-8

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Pregna-4,9(11)-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-17-hydroxy-16-methyl-, (6α,16α)-

Description:
Pregna-4,9(11)-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-17-hydroxy-16-methyl-, (6α,16α)-, commonly known as a synthetic steroid, exhibits several notable characteristics. This compound belongs to the class of corticosteroids and is primarily used for its anti-inflammatory and immunosuppressive properties. Its structure features a steroid backbone with specific functional groups, including a fluorine atom, which can enhance its potency and metabolic stability. The presence of an acetyloxy group contributes to its solubility and bioavailability. The compound's stereochemistry, indicated by the (6α,16α) configuration, plays a crucial role in its biological activity and interaction with steroid receptors. As a synthetic derivative, it may exhibit a range of pharmacological effects, including modulation of gene expression and influence on various physiological processes. Due to its specific modifications, this compound is often utilized in therapeutic applications, particularly in treating conditions that require anti-inflammatory intervention. However, like all steroids, it may also have potential side effects that warrant careful consideration in clinical use.
Formula:C24H31FO5
InChI:InChI=1S/C24H31FO5/c1-13-9-18-16-11-20(25)19-10-15(27)5-7-22(19,3)17(16)6-8-23(18,4)24(13,29)21(28)12-30-14(2)26/h6,10,13,16,18,20,29H,5,7-9,11-12H2,1-4H3/t13-,16-,18+,20+,22-,23+,24+/m1/s1
InChI key:InChIKey=YOLRNVJDBSRWRR-MQANLOPGSA-N
SMILES:C[C@@]12[C@]([C@]3(C([C@]4(C)C([C@@H](F)C3)=CC(=O)CC4)=CC1)[H])(C[C@@H](C)[C@@]2(C(COC(C)=O)=O)O)[H]
Synonyms:
  • (6Alpha,16Alpha)-6-Fluoro-17-Hydroxy-16-Methyl-3,20-Dioxopregna-4,9(11)-Dien-21-Yl Acetate
  • 6alpha-Fluoro-17,21-dihydroxy-16alpha-methylpregna-4,9(11)-diene-3,20-dione 21-acetate
  • Pregna-4,9(11)-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-17-hydroxy-16-methyl-, (6α,16α)-
  • Pregna-4,9(11)-diene-3,20-dione, 6α-fluoro-17,21-dihydroxy-16α-methyl-, 21-acetate
  • U 24067
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Found 1 products.
  • 6α-Fluoro-17,21-Dihydroxy-16α-Methylpregna-4,9(11)-Diene-3,20-Dione 21-Acetate
    Biosynth
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    6α-Fluoro-17,21-Dihydroxy-16α-Methylpregna-4,9(11)-Diene-3,20-Dione 21-Acetate

    Controlled Product
    CAS:
    <p>6alpha-Fluoro-17,21-Dihydroxy-16alpha-Methylpregna-4,9(11)-Diene-3,20-Dione 21-Acetate is a synthetic angiostatic agent that inhibits the angiogenic process by affecting the growth of new blood vessels. It has been shown to inhibit proteolytic activity and to have an inhibitory effect on tumour necrosis factor-α (TNF-α) induced activation of endothelial cells and their proliferation. 6alpha-Fluoro-17,21-Dihydroxy-16alpha-Methylpregna-4,9(11)-Diene 3,20 Dione 21 Acetate also inhibits the growth of fetal bovine aortic endothelial cells in culture. The drug was also found to significantly reduce the monolayer cell viability after uptake by endothelial cells.</p>
    Formula:C24H31FO5
    Purity:Min. 95%
    Molecular weight:418.5 g/mol

    Ref: 3D-FF101262

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