CAS 188181-42-2

5'-O-[9(E)-Octadecenoyl]-1-beta-D-arabinofuranosylcytosine

Description:

5'-O-[9(E)-Octadecenoyl]-1-beta-D-arabinofuranosylcytosine, with the CAS number 188181-42-2, is a synthetic nucleoside analog that features a unique structure combining a cytosine base with an arabinofuranosyl sugar moiety and a fatty acid chain. This compound is characterized by its 5'-O-acylation, which enhances its lipophilicity, potentially improving cellular uptake and bioavailability. The presence of the 9(E)-octadecenoyl group, a long-chain unsaturated fatty acid, contributes to its amphiphilic nature, making it of interest in drug delivery systems and therapeutic applications. The arabinofuranosyl configuration of the sugar distinguishes it from the more common ribofuranosyl and deoxyribofuranosyl nucleosides, which may influence its biological activity and interaction with nucleic acid targets. This compound has been studied for its potential antiviral and anticancer properties, as modifications to nucleosides can alter their pharmacological profiles. Overall, its unique structural features make it a subject of interest in medicinal chemistry and pharmaceutical research.

Formula: C₂₇H₄₅N₃O₆

Synonyms:

• Elaidic acid-Cytarabine
• P-4055
• 4-Amino-1-[5-O-[9(E)-octadecenoyl]-beta-D-arabinofuranosyl]-2(1H)-pyrimidinone
• Elacytarabine

5'-O-(Elaidoyl) 1-β-D-arabinofuranosylcytosine

CAS: 188181-42-2

Formula: C₂₇H₄₅N₃O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 507.6627

Ref: IN-DA00ANSE

Elacytarabine

CAS: 188181-42-2

Elacytarabine

Purity: ≥95%

Molecular weight: 507.66g/mol

Ref: 54-BUP09860

(E)-((2R,3S,4S,5R)-5-(4-Amino-2-Oxopyrimidin-1(2H)-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl Octadec-9-Enoate

CAS: 188181-42-2

(E)-((2R,3S,4S,5R)-5-(4-Amino-2-Oxopyrimidin-1(2H)-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl Octadec-9-Enoate

Purity: 98%

Molecular weight: 507.66g/mol

Ref: 54-OR1023097

Elacytarabine

CAS: 188181-42-2

Elacytarabine is a cytotoxic compound that exhibits minimal toxicity to normal cells. It has a hydrophobic effect and binds to intracellular targets, such as the fatty acid acyl chain of proteins. Elacytarabine is an analog of cytarabine and inhibits DNA synthesis by binding to the RNA polymerase II enzyme. It can also bind to epidermal growth factor receptor, which leads to apoptosis in cancer cells. Elacytarabine has been shown to be effective against solid tumours in rodents, with minimal toxicity profiles.

Formula: C₂₇H₄₅N₃O₆

Purity: Min. 95%

Molecular weight: 507.66 g/mol

Ref: 3D-NHA18142

Elacytarabine

CAS: 188181-42-2

Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.

Formula: C₂₇H₄₅N₃O₆

Purity: 97.69%

Color and Shape: Solid

Molecular weight: 507.66

Ref: TM-T15009