CAS 1882-82-2
:21-Deoxycortisone
Description:
21-Deoxycortisone, also known as 21-deoxycorticosterone, is a steroid hormone that is classified as a mineralocorticoid. It is a derivative of corticosterone and is primarily involved in the regulation of electrolyte and water balance in the body. The chemical structure of 21-deoxycortisone features a steroid backbone with specific functional groups that influence its biological activity. It is characterized by the absence of a hydroxyl group at the C21 position, which distinguishes it from its parent compound, corticosterone. This modification affects its affinity for mineralocorticoid receptors and its overall physiological effects. 21-Deoxycortisone is synthesized in the adrenal cortex and plays a role in the renin-angiotensin-aldosterone system, impacting blood pressure and fluid balance. In clinical settings, it may be studied for its potential effects on conditions related to adrenal insufficiency or hypertension. As with many steroid hormones, its activity can be influenced by various factors, including enzymatic conversion and receptor interactions.
Formula:C21H28O4
InChI:InChI=1S/C21H28O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-16,18,25H,4-9,11H2,1-3H3/t15-,16-,18+,19-,20-,21-/m0/s1
InChI key:InChIKey=PUKLDDOGISCFCP-JSQCKWNTSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(C(=O)C1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]
Synonyms:- 17-Alpha-Hydroxypregn-4-Ene-3,11,20-Trione
- 17-Hydroxypregn-4-Ene-3,11,20-Trione
- 17α-Hydroxy-11-oxoprogesterone
- 17α-Hydroxypregn-4-ene-3,11,20-trione
- 21-Deoxycortisone
- 21-Desoxycortisone
- 4-Pregnene-17α-ol-3,11,20-trione
- 6-Pregn-4-en-17α-ol-3,11,20-trione
- NSC 38722
- Pregn-4-ene-3,11,20-trione, 17-hydroxy-
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Found 8 products.
21-Deoxy Cortisone
CAS:<p>21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is generated from 11-ketoprogesterone by the cytochrome P450 (CYP) isoform CYP17A1, and can also be produced by oxidation via 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) from 21-deoxycorticosterone. In patients with congenital adrenal hyperplasia, a metabolic disorder characterized by a deficiency of 21-hydroxylase, levels of 21-Deoxy Cortisone are elevated.</p>Formula:C21H28O4Color and Shape:SolidMolecular weight:344.444-Pregnen-17α-ol-3,11,20-trione-2,2,4,6,6,9,21,21,21-d9
CAS:Purity:98 atom % DColor and Shape:White SolidMolecular weight:353.5021-Deoxy Cortisone
CAS:Controlled Product<p>Applications A Cortisone derivative, a glucocorticoid.<br>References Mickelson, K., et al.: Biochemistry, 20, 6211 (1981), Westphal, U., et al.: J. Steroid Biochem., 19, 1 (1983),<br></p>Formula:C21H28O4Color and Shape:NeatMolecular weight:344.444-Pregnen-17α-ol-3,11,20-trione-2,2,4,6,6,9,21,21,21-d9
CAS:Controlled ProductFormula:C21D9H19O4Color and Shape:NeatMolecular weight:353.5121-Deoxycortisone
CAS:Controlled Product<p>21-Deoxycortisone is a synthetic glucocorticoid that is used to treat inflammatory and autoimmune disorders. Unlike other synthetic glucocorticoids, it has a high affinity for the mineralocorticoid receptor and can be used in the treatment of adrenal insufficiency. 21-Deoxycortisone binds to the 17-hydroxyprogesterone receptor and inhibits the enzyme phospholipase A2. This prevents arachidonic acid from being released into the cell membrane, which blocks prostaglandin synthesis and reduces inflammation. 21-Deoxycortisone has been shown to have anti-inflammatory properties in vitro by preventing the release of reactive oxygen species from mitochondria in calf thymus DNA. It also inhibits mitochondrial respiration in celastrus angulatus, an effect that is blocked by incubation with hydroxyl group substrates such as phosphorus pentoxide or water. The mechanism of action of this drug</p>Formula:C21H28O4Purity:Min. 95%Color and Shape:PowderMolecular weight:344.44 g/mol
