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CAS 188259-69-0

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4-Hydroxy Valsartan, Mixture of Diastereomers

Description:
4-Hydroxy Valsartan, a mixture of diastereomers, is a derivative of Valsartan, an angiotensin II receptor antagonist used primarily in the treatment of hypertension and heart failure. This compound features a hydroxyl group at the fourth position of the valsartan structure, which contributes to its pharmacological properties. The presence of multiple diastereomers indicates that the substance can exist in different spatial arrangements, affecting its biological activity and interactions. Typically, such compounds exhibit good solubility in organic solvents and moderate solubility in water, which can influence their bioavailability. The molecular structure includes a biphenyl moiety and a carboxylic acid group, which are essential for its receptor binding. As with many pharmaceutical compounds, the safety profile, efficacy, and potential side effects are determined by the specific diastereomeric forms present in the mixture. Overall, 4-Hydroxy Valsartan serves as an important compound in cardiovascular pharmacotherapy, with ongoing research into its therapeutic potential and mechanisms of action.
Formula:C24H29N5O4
InChI:InChI=1/C24H29N5O4/c1-15(2)22(24(32)33)29(21(31)13-8-16(3)30)14-17-9-11-18(12-10-17)19-6-4-5-7-20(19)23-25-27-28-26-23/h4-7,9-12,15-16,22,30H,8,13-14H2,1-3H3,(H,32,33)(H,25,26,27,28)/t16?,22-/m0/s1
SMILES:CC(C)[C@@H](C(=O)O)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CCC(C)O
Synonyms:
  • (S)-2-{(4(R,S)-Hydroxy-pentanoyl)-[2(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amino}-3-methyl-butyric Acid
  • Cgp 71580
  • N-(4-Hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
  • N-(4-hydroxypentanoyl)-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
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