CAS 188627-80-7

Eptifibatide

Description:

Eptifibatide is a synthetic cyclic heptapeptide that functions as a potent antiplatelet agent, primarily used in the management of acute coronary syndromes and during percutaneous coronary interventions. It acts as a reversible inhibitor of the glycoprotein IIb/IIIa receptor on platelets, thereby preventing platelet aggregation and thrombus formation. Eptifibatide is derived from the venom of the southeastern pygmy rattlesnake and is characterized by its specific binding affinity to the receptor, which is crucial for platelet activation. The substance is typically administered intravenously and has a relatively short half-life, necessitating continuous infusion in clinical settings. Eptifibatide is generally well-tolerated, although it may be associated with bleeding risks, particularly in patients with a history of bleeding disorders or those undergoing surgical procedures. Its pharmacokinetics and pharmacodynamics make it a valuable tool in acute cardiovascular care, contributing to improved outcomes in high-risk patients.

Formula: C₃₅H₄₉N₁₁O₉S₂

InChI: InChI=1/C35H49N11O9S2/c36-31(52)26-17-57-56-12-10-27(47)43-22(7-3-4-11-39-35(37)38)32(53)41-16-28(48)44-25(14-29(49)50)34(55)45-24(13-18-15-40-20-6-2-1-5-19(18)20)30(51)21-8-9-23(42-21)33(54)46-26/h1-2,5-6,15,21-26,40,42H,3-4,7-14,16-17H2,(H2,36,52)(H,41,53)(H,43,47)(H,44,48)(H,45,55)(H,46,54)(H,49,50)(H4,37,38,39)/t21?,22-,23-,24-,25-,26-/m0/s1

SMILES: c1ccc2c(c1)c(C[C@H]1C(=O)C3CC[C@@H](C(=N[C@@H](CSSCCC(=N[C@@H](CCCCNC(=N)N)C(=NCC(=N[C@@H](CC(=O)O)C(=N1)O)O)O)O)C(=N)O)O)N3)c[nH]2

Synonyms:

• [3-carbamoyl-11-{4-[(diaminomethylidene)amino]butyl}-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
• [(1S,4R,12S,18S,21S)-12-(4-carbamimidamidobutyl)-4-carbamoyl-21-(1H-indol-3-ylmethyl)-2,10,13,16,19,22-hexaoxo-6,7-dithia-3,11,14,17,20,26-hexaazabicyclo[21.2.1]hexacos-18-yl]acetic acid
• Map-Lys-Gly-Asp-Trp-Pro-Cys-Nh2
• Integrelin
• N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-L-a-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide
• [(3R,11S,17S,20S,25aS)-11-(4-carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
• Eptifibatide Acetate

Eptifibatide

CAS: 188627-80-7

Eptifibatide, a RGD mimetic, is a glycoprotein (GP) IIb/IIIa receptor antagonist. Clinically, the peptide is used as an antiplatelet drug in combination with heparin and aspirin in the management of unstable angina and in patients undergoing coronary angioplasty and stenting procedures. CAS Number (eptifibatide acetate): 148031-34-9.

Formula: C₃₅H₄₉N₁₁O₉S₂

Purity: ≥99%

Color and Shape: White Lyophilisate

Molecular weight: 831.97

Ref: 01-4063191

Eptifibatide

CAS: 188627-80-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₃₅H₄₉N₁₁O₉S₂

Color and Shape: White Powder

Molecular weight: 831.31561

Ref: 45-1238501

L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 831.9619

Ref: IN-DA001FDT

Eptifibatide

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Molecular weight: 831.96

Ref: 7W-GP0493

Eptifibatide Acetate

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 831.962

Ref: BP-BPPG027

Eptifibatide

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Molecular weight: 831.97

Ref: 4Z-PE-126001

Human Eptifibatide

CAS: 188627-80-7

Human Eptifibatide

Color and Shape: White Lyophilised Powder

Molecular weight: 831.96g/mol

Ref: 54-BITP1545

Eptifibatide

Controlled Product

CAS: 188627-80-7

Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.
References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),

Formula: C₃₅H₄₉N₁₁O₉S₂

Color and Shape: Off White Solid

Molecular weight: 831.96

Ref: TR-E592000

Eptifibatide acetate

Controlled Product

CAS: 188627-80-7

Inhibits platelet glycoprotein IIb/IIIa receptors

Formula: C₃₅H₄₉N₁₁O₉S₂·xC₂H₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 831.96 g/mol

Ref: 3D-FE40869

Eptifibatide

CAS: 188627-80-7

Eptifibatide is a drug that is used in the treatment of congestive heart failure, acute coronary syndrome and peripheral artery disease. It is a glycoprotein IIb/IIIa inhibitor that binds to integrin receptors on platelets and prevents them from binding to fibrinogen. This prevents blood clotting and reduces the risk of stroke or heart attack. Eptifibatide has been shown to be effective for the treatment of bowel disease, infectious diseases, and experimental models of myocardial infarcts. The drug has significant cytotoxicity, which may be due to its ability to inhibit cell proliferation by blocking protein synthesis at the ribosome level.
Eptifibatide has been shown to have a disulfide bond between two cysteine residues located in its amino-terminal region. This bond stabilizes the molecule in solution and ensures that it remains active until it reaches its target site.

Formula: C₃₅H₄₉N₁₁O₉S₂

Purity: Min. 95%

Molecular weight: 831.98 g/mol

Ref: 3D-EPT-3786-PI