CAS 18865-48-0

actinomycin V from streptomyces*antibioticus

Description:

Actinomycin V, a member of the actinomycin family, is a potent antibiotic produced by the bacterium Streptomyces antibioticus. It is characterized by its complex polypeptide structure, which includes a phenoxazone chromophore and a series of amino acids that contribute to its biological activity. Actinomycin V exhibits strong antitumor properties, primarily by intercalating into DNA and inhibiting RNA synthesis, making it valuable in cancer treatment research. This compound is known for its low solubility in water, which can affect its bioavailability and therapeutic application. Additionally, it has a relatively high molecular weight and specific stereochemistry that influence its interaction with cellular components. Due to its potent biological effects, actinomycin V is handled with care in laboratory settings, as it can be toxic to both cancerous and healthy cells. Its use is primarily restricted to research and clinical settings, where it is studied for its mechanisms of action and potential therapeutic applications in oncology.

Formula: C₆₂H₈₄N₁₂O₁₇

InChI: InChI=1/C62H84N12O17/c1-26(2)42-59(85)73-21-17-18-36(73)57(83)69(13)24-38(76)71(15)48(28(5)6)61(87)89-32(11)44(55(81)65-42)67-53(79)35-20-19-30(9)51-46(35)64-47-40(41(63)50(78)31(10)52(47)91-51)54(80)68-45-33(12)90-62(88)49(29(7)8)72(16)39(77)25-70(14)58(84)37-22-34(75)23-74(37)60(86)43(27(3)4)66-56(45)82/h19-20,26-29,32-33,36-37,42-45,48-49H,17-18,21-25,63H2,1-16H3,(H,65,81)(H,66,82)(H,67,79)(H,68,80)/t32-,33-,36+,37+,42-,43-,44+,45+,48?,49+/m1/s1

Synonyms:

• Actinomycin X2
• 1H-Pyrrolo(2,1-i)(1,4,7,10,13)oxatetraazacyclohexadecine, cyclic peptide deriv.
• 3H-Phenoxazine, actinomycin D deriv.
• Actinomycin D, 3A-(4-oxo-L-proline)-
• Actinomycin-V
• 2-amino-4,6-dimethyl-3-oxo-N~1~-[2,5,9-trimethyl-1,4,7,11,14,17-hexaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-N~9~-[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-di(propan-2-yl)hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-3H-phenoxazine-1,9-dicarboxamide
• 2-amino-N1-[(3R,6S,7R,10S,16S)-3,10-diisopropyl-7,11,14-trimethyl-2,5,9,12,15,18-hexaoxo-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-N9-[(3R,6S,7R,10S,16S)-3,10-diisopropyl-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxo-phenoxazine-1,9-dicarboxamide

Actinomycin X2

CAS: 18865-48-0

Formula: C₆₂H₈₄N₁₂O₁₇

Molecular weight: 1269.4

Ref: 7W-GL3366

Actinomycin V

CAS: 18865-48-0

An analogue of Actinomycin D and an antitumor agent. Due to lower hepatotoxicity, Actinomycin V is more often used than Actynomycin D in chemotherapy and shows great efficiency against human breast cancer cells.

Formula: C₆₂H₈₄N₁₂O₁₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,269.4 g/mol

Ref: 3D-AA65679

Actinomycin X2

CAS: 18865-48-0

Formula: C₆₂H₈₄N₁₂O₁₇

Molecular weight: 1269.4

Ref: ST-EA-CP-D138001