CAS 188696-80-2

Becampanel

Description:

Becampanel is a chemical compound primarily recognized for its role as a selective antagonist of the AMPA receptor, which is a subtype of glutamate receptors in the central nervous system. This compound is notable for its potential therapeutic applications in treating neurological disorders, particularly those associated with excitotoxicity, such as epilepsy and neurodegenerative diseases. Becampanel exhibits a unique structure that allows it to effectively bind to the AMPA receptor, inhibiting its activity and thereby modulating synaptic transmission. Its pharmacological profile suggests that it may help in reducing neuronal excitability and protecting against neuronal damage. The compound has undergone various stages of clinical trials to evaluate its efficacy and safety in humans. As with many pharmacological agents, the specific characteristics, including solubility, stability, and metabolic pathways, are crucial for its development and application in medical settings. Overall, becampanel represents a significant area of interest in neuropharmacology due to its targeted action on glutamate receptors.

Formula: C₁₀H₁₁N₄O₇P

InChI: InChI=1/C10H11N4O7P/c15-9-10(16)13-8-5(3-11-4-22(19,20)21)1-6(14(17)18)2-7(8)12-9/h1-2,11H,3-4H2,(H,12,15)(H,13,16)(H2,19,20,21)

InChI key: InChIKey=ABFMMCZFKUIJGQ-UHFFFAOYSA-N

SMILES: C(NCP(=O)(O)O)C1=C2C(=CC(N(=O)=O)=C1)NC(=O)C(=O)N2

Synonyms:

• ({[(7-Nitro-2,3-Dioxo-1,2,3,4-Tetrahydroquinoxalin-5-Yl)Methyl]Amino}Methyl)Phosphonic Acid
• Amp-397
• Amp-397A
• Becampanel
• P-[[[(1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-5-quinoxalinyl)methyl]amino]methyl]phosphonic acid
• Phosphonic acid, P-[[[(1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-5-quinoxalinyl)methyl]amino]methyl]-
• Phosphonic acid, [[[(1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-5-quinoxalinyl)methyl]amino]methyl]-

Amp 397

CAS: 188696-80-2

Formula: C₁₀H₁₁N₄O₇P

Molecular weight: 330.1907

Ref: IN-DA002H5L

Becampanel

CAS: 188696-80-2

Becampanel is a linker drug that binds to the adenosine A1 receptor and blocks nerve transmission. It is used to treat chronic pain, postoperative pain, and neuropathic pain. Becampanel has been shown to be effective in reducing diabetic neuropathy and Alzheimer's disease. This drug has been shown to have a synergistic effect when combined with cholinesterase inhibitors, which are drugs that inhibit the breakdown of acetylcholine by cholinesterases. The combination of becampanel with an acetylcholine esterase inhibitor produces a significant reduction in the symptoms of chronic pain.

Formula: C₁₀H₁₁N₄O₇P

Purity: Min. 95%

Molecular weight: 330.19 g/mol

Ref: 3D-NHA69680

Becampanel

CAS: 188696-80-2

Becampanel (AMP397) is the first competitive AMPA antagonist. Becampanel (AMP397) also is an antiepileptic agent.

Formula: C₁₀H₁₁N₄O₇P

Purity: 98%

Color and Shape: Solid

Molecular weight: 330.19

Ref: TM-T14281