CAS 1887043-58-4

2,4-Imidazolidinedione, 3-[(2R)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropyl]-5-(4-fluorophenyl)-5-methyl-, (5S)-rel-

Description:

2,4-Imidazolidinedione, 3-[(2R)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropyl]-5-(4-fluorophenyl)-5-methyl-, (5S)-rel- is a complex organic compound characterized by its imidazolidinedione core structure, which is a five-membered ring containing two nitrogen atoms and two carbonyl groups. This compound features a chiral center, contributing to its stereochemistry, specifically the (5S)-configuration. The presence of a piperazine moiety indicates potential pharmacological activity, as piperazine derivatives are often associated with various biological effects. Additionally, the incorporation of a fluorophenyl group suggests enhanced lipophilicity and potential interactions with biological targets. The hydroxyl group on the hydroxypropyl chain may contribute to solubility and reactivity. Overall, this compound's structural complexity and functional groups suggest it may have applications in medicinal chemistry, particularly in the development of therapeutic agents. However, specific biological activities and safety profiles would require further investigation through empirical studies.

Synonyms:

• 2,4-Imidazolidinedione, 3-[(2R)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropyl]-5-(4-fluorophenyl)-5-methyl-, (5S)-rel-

5-HT7R antagonist 3

CAS: 1887043-58-4

Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.

Formula: C₃₀H₃₃FN₄O₃

Color and Shape: Solid

Molecular weight: 516.61

Ref: TM-T201849