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CAS 188717-17-1

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Montelukast Acyl-b-D-glucuronide

Description:
Montelukast Acyl-β-D-glucuronide is a metabolite of Montelukast, a leukotriene receptor antagonist primarily used in the management of asthma and allergic rhinitis. This compound is characterized by its glucuronidation, a common phase II metabolic process where a glucuronic acid moiety is conjugated to a drug or its metabolite, enhancing its solubility and facilitating excretion. The structure of Montelukast Acyl-β-D-glucuronide includes a glucuronic acid unit linked to the Montelukast molecule, which contributes to its pharmacokinetic properties. This metabolite is generally less active than the parent compound but may still play a role in the overall therapeutic effects and safety profile of Montelukast. Its solubility in water is increased due to the glucuronide formation, which aids in renal excretion. Understanding the characteristics of this metabolite is crucial for evaluating the drug's metabolism, efficacy, and potential side effects in clinical settings.
Synonyms:
  • 1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetate] b-D-Glucopyranuronic Acid
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