CAS 18887-18-8

Hydroxytanshinone IIA

Description:

Hydroxytanshinone IIA is a bioactive compound derived from the roots of the traditional Chinese medicinal plant Salvia miltiorrhiza, commonly known as Danshen. This compound is part of the tanshinone family and is recognized for its potential therapeutic properties, including anti-inflammatory, antioxidant, and anticancer activities. Hydroxytanshinone IIA exhibits a complex molecular structure characterized by multiple rings and functional groups, which contribute to its biological activity. It is typically studied for its effects on various cellular pathways and its ability to modulate oxidative stress. The compound is soluble in organic solvents but has limited solubility in water, which can influence its bioavailability and pharmacokinetics. Research continues to explore its mechanisms of action and potential applications in treating cardiovascular diseases and other health conditions. As with many natural products, the efficacy and safety of Hydroxytanshinone IIA require further investigation through clinical studies to fully understand its therapeutic potential.

Formula: C₁₉H₁₈O₄

InChI: InChI=1S/C19H18O4/c1-9-8-23-18-10-4-5-11-15(12(20)6-7-19(11,2)3)14(10)17(22)16(21)13(9)18/h4-5,8,12,20H,6-7H2,1-3H3

InChI key: InChIKey=UPCWCCRFMPIOAP-UHFFFAOYSA-N

SMILES: O=C1C2=C3C(C(C)(C)CCC3O)=CC=C2C4=C(C1=O)C(C)=CO4

Synonyms:

• 6,7,8,9-Tetrahydro-9-hydroxy-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
• Hydroxytanshinone II
• Hydroxytanshinone IIA
• Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-9-hydroxy-1,6,6-trimethyl-

Hydroxytanshinone IIA

CAS: 18887-18-8

Hydroxytanshinone IIA strongly inhibits SGC-7901, HeLa, HepG2 cells with IC50 values: 4.18, 6.08, 10.20 uM, outperforming tanshinone IIA.

Formula: C₁₉H₁₈O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 310.34

Ref: TM-TN4239

Hydroxytanshinone IIA

CAS: 18887-18-8

Hydroxytanshinone IIA is a bioactive compound, which is a diterpene quinone derived from the root of Salvia miltiorrhiza, commonly known as Danshen. This compound exhibits a range of biological activities primarily due to its anti-inflammatory and antioxidant properties. The mode of action involves the inhibition of key signaling pathways and enzymes involved in oxidative stress and inflammation, such as NF-kB and COX-2, respectively.

Formula: C₁₉H₁₈O₄

Purity: Min. 95%

Molecular weight: 310.30 g/mol

Ref: 3D-TAA88718