CAS 188968-51-6

2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid

Description:

The chemical substance known as 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid, with the CAS number 188968-51-6, is a complex organic compound characterized by its multi-cyclic structure and the presence of multiple functional groups. This compound features a pentazacyclopentadecane backbone, which contributes to its unique three-dimensional conformation and potential biological activity. The presence of a benzyl group and a diaminomethylideneamino moiety suggests that it may exhibit interesting interactions with biological targets, possibly influencing its pharmacological properties. Additionally, the acetic acid functional group indicates potential for solubility in polar solvents and may play a role in the compound's reactivity. Overall, this substance's intricate structure and functional diversity make it a candidate for further investigation in medicinal chemistry and related fields.

Formula: C₂₇H₄₀N₈O₇

InChI: InChI=1/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1

Synonyms:

• Cilengitide
• cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
• cyclo[L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl-N~5~-(diaminomethylidene)-L-ornithylglycyl]

Cilengitide

CAS: 188968-51-6

The cyclic RGD peptide cilengitide is a potential cancer drug. Cilengitide is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.

Formula: C₂₇H₄₀N₈O₇

Purity: 97.6%

Color and Shape: White

Molecular weight: 588.66

Ref: 01-4060586

Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl)

CAS: 188968-51-6

Formula: C₂₇H₄₀N₈O₇

Purity: 90%

Color and Shape: Solid

Molecular weight: 588.6559

Ref: IN-DA002HLG

Cilengitide

CAS: 188968-51-6

Cilengitide

Purity: ≥98%

Molecular weight: 588.66g/mol

Ref: 54-BUP07988

Cilengitide

CAS: 188968-51-6

Formula: C₂₇H₄₀N₈O₇

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 588.66

Ref: BP-BPPG018

Cilengitide

CAS: 188968-51-6

Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.

Formula: C₂₇H₄₀N₈O₇

Purity: 98% - 99.8%

Color and Shape: Solid

Molecular weight: 588.66

Ref: TM-T2494

Cilengitide

CAS: 188968-51-6

Cilengitide is a new chemotherapeutic agent that was shown to be effective against renal cell cancer in vitro. Cilengitide inhibits the polymerase chain reaction, arresting the growth of cells. It has minimal toxicity and natural compounds, which make it a promising drug for the treatment of human cancers. Cilengitide binds to integrin receptors on malignant brain cells and inhibits their ability to migrate, inducing apoptosis. This drug also inhibits the production of chemoattractant protein and can be used as an adjuvant therapy for radiation and antibiotic-resistant strains of bacteria.

Formula: C₂₇H₄₀N₈O₇

Purity: Min. 95%

Molecular weight: 588.67 g/mol

Ref: 3D-RGD-3036-PI

Cilengitide

CAS: 188968-51-6

Purity: 98%

Molecular weight: 588.302

Ref: 10-F813353

Cilengitide

CAS: 188968-51-6

Cilengitide is a peptide that inhibits the integrin receptor, which may be involved in tumorigenesis. It blocks the process of cellular transformation and inhibits tumor growth by blocking angiogenesis. Cilengitide has been shown to have minimal toxicity in vitro and in vivo, which is likely due to its low solubility in water. This peptide also has antitumor activity against solid tumours and can inhibit the growth of human breast cancer cells. Cilengitide was found to be effective in an experimental model using MDA-MB-231 breast cancer cells, demonstrating its potential for use as a therapeutic agent for cancer treatment.

Formula: C₂₇H₄₀N₈O₇

Purity: Min. 95%

Molecular weight: 588.66 g/mol

Ref: 3D-NHA96851