CAS 189059-71-0

Lapaquistat

Description:

Lapaquistat, identified by its CAS number 189059-71-0, is a synthetic compound primarily studied for its potential role in the treatment of hyperlipidemia and related cardiovascular conditions. It functions as an inhibitor of the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism and absorption. By inhibiting this enzyme, Lapaquistat aims to reduce cholesterol levels in the bloodstream, thereby potentially lowering the risk of atherosclerosis and other cardiovascular diseases. The compound is characterized by its specific molecular structure, which includes functional groups that contribute to its biological activity. In preclinical and clinical studies, Lapaquistat has demonstrated efficacy in modulating lipid profiles, although its safety and long-term effects are subjects of ongoing research. As with many pharmacological agents, understanding its pharmacokinetics, pharmacodynamics, and potential side effects is essential for evaluating its therapeutic potential. Overall, Lapaquistat represents a promising avenue in lipid management, although further studies are necessary to fully establish its clinical utility.

Formula: C₃₁H₃₉ClN₂O₈

InChI: InChI=1S/C31H39ClN2O8/c1-31(2,18-35)17-34-23-9-8-20(32)15-22(23)28(21-6-5-7-24(40-3)29(21)41-4)42-25(30(34)39)16-26(36)33-12-10-19(11-13-33)14-27(37)38/h5-9,15,19,25,28,35H,10-14,16-18H2,1-4H3,(H,37,38)/t25-,28-/m1/s1

InChI key: InChIKey=HDGUKVZPMPJBFK-LEAFIULHSA-N

SMILES: O(C)C1=C([C@@H]2C=3C(N(CC(CO)(C)C)C(=O)[C@@H](CC(=O)N4CCC(CC(O)=O)CC4)O2)=CC=C(Cl)C3)C=CC=C1OC

Synonyms:

• 1-[2-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
• 4-Piperidineacetic acid, 1-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
• 4-Piperidineacetic acid, 1-[[7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-, (3R-trans)-
• 4-piperidineacetic acid, 1-[2-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
• Lapaquistat
• T 91485

2-(1-(2-((3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid

CAS: 189059-71-0

2-(1-(2-((3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid

Purity: 98%

Molecular weight: 603.11g/mol

Ref: 54-OR1067096

Lapaquistat

CAS: 189059-71-0

Lapaquistat is a drug that inhibits the activity of protein kinase C-ε, which plays a role in regulating cholesterol synthesis. It also acts as an inhibitor of hydroxyl methyl transferase, which is involved in cholesterol synthesis. This mechanism reduces the production of low-density lipoprotein (LDL) cholesterol and other lipids. Lapaquistat has been shown to be well tolerated in clinical trials and has no significant adverse effects on blood pressure or heart rate. The chemical stability of lapaquistat was demonstrated by its ability to inhibit thp-1 cells in culture for up to 72 hours at temperatures up to 50°C.

Formula: C₃₁H₃₉ClN₂O₈

Purity: Min. 95%

Molecular weight: 603.1 g/mol

Ref: 3D-PHA05971

Lapaquistat

CAS: 189059-71-0

Lapaquistat: active TAK-475 metabolite; reduces cholesterol synthesis and statin myotoxicity.

Formula: C₃₁H₃₉ClN₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 603.1

Ref: TM-T15710