CAS 189060-13-7: LAPAQUISTAT

Description: Lapaquistat, identified by its CAS number 189060-13-7, is a chemical compound that functions primarily as a pharmacological agent. It is known for its role as a selective inhibitor of the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which is involved in cholesterol metabolism. This inhibition can lead to a reduction in cholesterol absorption and may have implications for treating conditions related to dyslipidemia and cardiovascular diseases. Lapaquistat is characterized by its specific molecular structure, which contributes to its biological activity and selectivity. The compound has undergone various studies to evaluate its efficacy and safety profile in clinical settings. As with many pharmaceutical agents, its use may be associated with potential side effects, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its therapeutic potential. Overall, Lapaquistat represents a significant area of interest in the development of cholesterol-lowering therapies.

Formula: C₃₃H₄₁ClN₂O₉

InChI: InChI=1S/C33H41ClN2O9/c1-20(37)44-19-33(2,3)18-36-25-10-9-22(34)16-24(25)30(23-7-6-8-26(42-4)31(23)43-5)45-27(32(36)41)17-28(38)35-13-11-21(12-14-35)15-29(39)40/h6-10,16,21,27,30H,11-15,17-19H2,1-5H3,(H,39,40)/t27-,30-/m1/s1

InChI key: InChIKey=CMLUGNQVANVZHY-POURPWNDSA-N

SMILES: O=C(OCC(C)(C)CN1C(=O)C(OC(C=2C=CC=C(OC)C2OC)C3=CC(Cl)=CC=C31)CC(=O)N4CCC(CC(=O)O)CC4)C

Synonyms:

• 1-((1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2\r
• ,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid
• 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
• 2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3- dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3- yl)acetyl)piperidin-4-yl)acetic acid
• 4-Piperidineacetic acid, 1-(((3R,5S)-1-(3-(acetyloxy)-2,2-dimethylpropyl)-7- chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3- yl)acetyl)-
• 4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
• 4-Piperidineacetic acid, 1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-, (3R-trans)-
• Lapaquistat acetate
• Lapaquistat acetate [USAN]
• Tak 475
• Unii-Iuh3Ay74O3

Lapaquistat Acetate

CAS: 189060-13-7

Applications A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by …

• Formula: C₃₃H₄₁ClN₂O₉
• Color and Shape: Neat
• Molecular weight: 645.14

Lapaquistat acetate

CAS: 189060-13-7

Please enquire for more information about Lapaquistat acetate including the price, delivery time and more …

• Formula: C₃₃H₄₁ClN₂O₉
• Purity: Min. 95%
• Molecular weight: 645.14 g/mol

Lapaquistat acetate

CAS: 189060-13-7

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins …

• Formula: C₃₃H₄₁ClN₂O₉
• Purity: 100% - 99.74%
• Color and Shape: Solid
• Molecular weight: 645.14