CAS 189188-57-6

Tegaserod maleate

Description:

Tegaserod maleate is a selective serotonin receptor agonist primarily used in the treatment of irritable bowel syndrome (IBS) and chronic constipation. It acts on the 5-HT4 receptor, promoting gastrointestinal motility and enhancing peristalsis. The substance is typically presented as a maleate salt, which improves its solubility and stability. Tegaserod is characterized by its ability to alleviate symptoms such as abdominal pain and discomfort associated with IBS. Its pharmacological profile includes a relatively short half-life, necessitating multiple doses for therapeutic efficacy. The compound is generally well-tolerated, although it may be associated with side effects such as headache, diarrhea, and abdominal pain. Due to safety concerns, particularly regarding cardiovascular risks, its use has been restricted in some regions. As with any medication, it is essential to consider individual patient factors and consult healthcare professionals for appropriate use. Overall, tegaserod maleate represents a targeted approach to managing specific gastrointestinal disorders.

Formula: C₁₆H₂₃N₅O·C₄H₄O₄

InChI: InChI=1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=CPDDZSSEAVLMRY-BTJKTKAUSA-N

SMILES: C(=NNC(NCCCCC)=N)C=1C=2C(NC1)=CC=C(OC)C2.C(=C\C(O)=O)\C(O)=O

Synonyms:

• (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate (1:1)
• 2-[(5-Methoxy-1H-Indole-3-Yl)Methylene]-N-Pentylcarbazimidamide Hydrogen Maleate
• 2-[(Z)-(5-methoxy-3H-indol-3-ylidene)methyl]-N'-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate
• Htf 919
• Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1)
• Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (Z)-2-butenedioate (1:1)
• Sdz-Htf 919
• Tegaserod Maleate
• Tegaserod hydrogen maleate
• Tegaserode
• Tegibs 6
• Zelmac

Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1)

CAS: 189188-57-6

Formula: C₂₀H₂₇N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 417.4589

Ref: IN-DA002I0V

Tegaserod maleate

CAS: 189188-57-6

Tegaserod (SDZ-HTF-919), a 5-HT4 agonist for irritable bowel syndrome, was withdrawn by FDA on March 30, 2007, due to heart risk concerns.

Formula: C₂₀H₂₇N₅O₅

Purity: 98% - 99.06%

Color and Shape: White Powder

Molecular weight: 417.46

Ref: TM-T1551

Tegaserod maleate

CAS: 189188-57-6

Tegaserod maleate

Purity: ≥98%

Molecular weight: 417.46g/mol

Ref: 54-BUP13748

Tegaserod-13C-d3 Maleate

CAS: 189188-57-6

Formula: C₁₅₁₃CH₂₀D₃N₅O·C₄H₄O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 305.40 116.07

Ref: 4Z-T-932

Tegaserod Maleate

CAS: 189188-57-6

Formula: C₁₆H₂₃N₅O·C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 301.39 116.07

Ref: 4Z-T-931

Tegaserod maleate

CAS: 189188-57-6

Formula: C₁₆H₂₃N₅O·C₄H₄O₄

Purity: ≥ 99.0% (dried basis)

Color and Shape: White powder

Molecular weight: 417.46

Ref: 7W-GP2443

Tegaserod Maleate

Controlled Product

CAS: 189188-57-6

Applications Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.
References Appel, S., et al.: Clin. Pharmacol. Ther., 62, 546 (1997),

Formula: C₁₆H₂₃N₅O·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 417.46

Ref: TR-T014500

Tegaserod maleate

CAS: 189188-57-6

5-HT4 serotonin receptor antagonist; used for treating irritable bowel syndrome

Formula: C₂₀H₂₇N₅O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 417.46 g/mol

Ref: 3D-FT28020

Tegaserod Maleate

CAS: 189188-57-6

Formula: C₁₆H₂₃N₅OC₄H₄O₄

Molecular weight: 301.39 : 116.07

Ref: ST-EA-CP-T86007