CAS 189188-57-6: Tegaserod maleate

Description: Tegaserod maleate is a selective serotonin receptor agonist primarily used in the treatment of irritable bowel syndrome (IBS) and chronic constipation. It acts on the 5-HT4 receptor, promoting gastrointestinal motility and enhancing peristalsis. The substance is typically presented as a maleate salt, which improves its solubility and stability. Tegaserod is characterized by its ability to alleviate symptoms such as abdominal pain and discomfort associated with IBS. Its pharmacological profile includes a relatively short half-life, necessitating multiple doses for therapeutic efficacy. The compound is generally well-tolerated, although it may be associated with side effects such as headache, diarrhea, and abdominal pain. Due to safety concerns, particularly regarding cardiovascular risks, its use has been restricted in some regions. As with any medication, it is essential to consider individual patient factors and consult healthcare professionals for appropriate use. Overall, tegaserod maleate represents a targeted approach to managing specific gastrointestinal disorders.

Formula: C₁₆H₂₃N₅O·C₄H₄O₄

InChI: InChI=1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=CPDDZSSEAVLMRY-BTJKTKAUSA-N

SMILES: O=C(O)C=CC(=O)O.N=C(NN=CC1=CNC=2C=CC(OC)=CC12)NCCCCC

Synonyms:

• (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate (1:1)
• 2-[(5-Methoxy-1H-Indole-3-Yl)Methylene]-N-Pentylcarbazimidamide Hydrogen Maleate
• 2-[(Z)-(5-methoxy-3H-indol-3-ylidene)methyl]-N'-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate
• Htf 919
• Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1)
• Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (Z)-2-butenedioate (1:1)
• Sdz-Htf 919
• Tegaserod Maleate
• Tegaserod hydrogen maleate
• Tegaserode
• Tegibs 6
• Zelmac
• Zelnorm

Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1)

CAS: 189188-57-6

• Formula: C₂₀H₂₇N₅O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 417.4589

Tegaserod maleate

CAS: 189188-57-6

Tegaserod (SDZ-HTF-919), a 5-HT4 agonist for irritable bowel syndrome, was withdrawn by FDA on March …

• Formula: C₂₀H₂₇N₅O₅
• Purity: 98% - 99.06%
• Color and Shape: White Powder
• Molecular weight: 417.46

Tegaserod Maleate

CAS: 189188-57-6

• Formula: C₁₆H₂₃N₅O·C₄H₄O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 301.39 116.07

Tegaserod-13C-d3 Maleate

CAS: 189188-57-6

• Formula: C₁₅₁₃CH₂₀D₃N₅O·C₄H₄O₄
• Color and Shape: Pale Yellow Solid
• Molecular weight: 305.40 116.07

Tegaserod maleate

CAS: 189188-57-6

• Formula: C₁₆H₂₃N₅O·C₄H₄O₄
• Purity: ≥ 99.0% (dried basis)
• Color and Shape: White powder
• Molecular weight: 417.46

Tegaserod Maleate

CAS: 189188-57-6

Applications Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective …

• Formula: C₁₆H₂₃N₅O·C₄H₄O₄
• Color and Shape: Neat
• Molecular weight: 417.46

Tegaserod maleate

CAS: 189188-57-6

5-HT4 serotonin receptor antagonist; used for treating irritable bowel syndrome

• Formula: C₂₀H₂₇N₅O₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 417.46 g/mol