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CAS 189261-10-7

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Immunoglobulin G4, anti-(human integrin α4) (human-mouse monoclonal AN100226 γ4-chain), disulfide with human-mouse monoclonal AN100226 light chain, dimer

Description:
Immunoglobulin G4 (IgG4) is a subclass of immunoglobulin G, characterized by its unique structure and function in the immune response. The specific substance you mentioned, anti-(human integrin α4), is a monoclonal antibody that targets the integrin α4, which plays a crucial role in cell adhesion and migration. This antibody is a dimer, meaning it consists of two identical units, and is formed by disulfide bonds between the heavy (γ4-chain) and light chains derived from human-mouse hybridoma technology. IgG4 is known for its reduced ability to activate complement and its unique capacity to undergo "Fab-arm exchange," which allows it to form bispecific antibodies. This property can enhance its therapeutic potential by targeting multiple antigens. The CAS number 189261-10-7 uniquely identifies this specific antibody, which is utilized in research and potential therapeutic applications, particularly in conditions involving immune modulation and inflammation. Overall, IgG4 antibodies are characterized by their specificity, reduced immunogenicity, and ability to modulate immune responses.
Formula:C40H55N7O11S
Synonyms:
  • Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer
  • Natalizumab-Tysabri
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