CAS 189275-71-6

Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

Description:

Ac-Trp-Glu-His-Asp-aldehyde, also known as a pseudo acid, is a synthetic peptide derivative characterized by its unique sequence of amino acids: tryptophan (Trp), glutamic acid (Glu), histidine (His), and aspartic acid (Asp), with an aldehyde functional group. This compound is typically used in biochemical research and pharmaceutical applications due to its potential interactions with biological systems. The presence of the aldehyde group can facilitate various chemical reactions, including condensation and reduction, making it a versatile building block in peptide synthesis. The specific arrangement of amino acids contributes to its biological activity, influencing properties such as solubility, stability, and reactivity. Additionally, the acetylation at the N-terminus may enhance its membrane permeability and bioavailability. Overall, Ac-Trp-Glu-His-Asp-aldehyde serves as an important tool in the study of peptide interactions and the development of therapeutic agents.

Formula: C₂₈H₃₃N₇O

Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

CAS: 189275-71-6

Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.

Formula: C₂₈H₃₃N₇O₉

Purity: 95.0%

Color and Shape: White

Molecular weight: 611.61

Ref: 01-4027878

Ac-Trp-Glu-His-Asp-Aldehyde

CAS: 189275-71-6

Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].

Formula: C₂₈H₃₃N₇O₉

Color and Shape: Solid

Molecular weight: 611.6

Ref: TM-T76600

Ac-Trp-Glu-His-Asp-H (aldehyde)

CAS: 189275-71-6

Ac-Trp-Glu-His-Asp-H (aldehyde) is a synthetic peptide that is used as a research tool for pharmacology. It is an activator of ion channels and has been shown to inhibit the activity of protein interactions. Ac-Trp-Glu-His-Asp-H (aldehyde) also shows high purity and no detectable impurities in the final product.

Formula: C₂₈H₃₃N₇O₉

Purity: Min. 95%

Molecular weight: 611.6 g/mol

Ref: 3D-ICA-3187-V

Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

CAS: 189275-71-6

Ac-Trp-Glu-His-Asp-aldehyde is a tetrapeptide that has been shown to inhibit the activity of caspases. Caspases are proteases that play an important role in cell death by inducing apoptosis and necrosis. The structure of the Ac-Trp-Glu-His-Asp-aldehyde was determined by X-ray crystallography, revealing a hydrophobic molecule with a pseudo acid residue. This compound binds to peptides and blocks the binding site for caspase substrates, which prevents their activation. Acetylation of this compound also increases its hydrophobicity, making it more likely to bind to other molecules such as proteins or lipids.

Formula: C₂₈H₃₃N₇O₉

Purity: Min. 95%

Molecular weight: 611.6 g/mol

Ref: 3D-FA111076