CAS 189279-58-1

Delafloxacin

Description:

Delafloxacin is a fluoroquinolone antibiotic characterized by its broad-spectrum activity against various Gram-positive and Gram-negative bacteria. It is particularly noted for its effectiveness against resistant strains, including methicillin-resistant Staphylococcus aureus (MRSA). The chemical structure of delafloxacin features a bicyclic core with a carboxylic acid group, which is essential for its antibacterial activity. It exhibits a unique mechanism of action by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Delafloxacin is typically administered orally or intravenously and is used to treat skin and skin structure infections, as well as respiratory tract infections. Its pharmacokinetic properties include good oral bioavailability and a favorable half-life, allowing for once or twice-daily dosing. Additionally, delafloxacin has a lower propensity for phototoxicity compared to other fluoroquinolones, making it a safer option for patients with increased sun exposure. Overall, delafloxacin represents a significant advancement in the treatment of bacterial infections, particularly in the context of rising antibiotic resistance.

Formula: C₁₈H₁₂ClF₃N₄O₄

InChI: InChI=1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)

InChI key: InChIKey=DYDCPNMLZGFQTM-UHFFFAOYSA-N

SMILES: ClC1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3CC(O)C3)C4=C(F)C=C(F)C(N)=N4

Synonyms:

• 1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid
• 3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-
• Abt-492
• Baxdela
• Delafloxacin
• Delafloxacinum
• Rx 3341
• Wq-3034
• 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 3-​ Quinolinecarboxylic acid, 1-​ (6-​ amino-​ 3,​ 5-​ difluoro-​ 2-​ pyridinyl)​ -​ 6-​ fluoro-​ 1,​ 4-​ dihydro-​ 7-​ [3-​ (2-​ methyl-​ 1-​ oxopropoxy)​ -​ 1-​ azetidinyl]​ -​ 4-​ oxo-​ , ethyl ester

3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-

CAS: 189279-58-1

Formula: C₁₈H₁₂ClF₃N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 440.7605

Ref: IN-DA002I64

Delafloxacin

CAS: 189279-58-1

Delafloxacin

Purity: 98%

Molecular weight: 440.76g/mol

Ref: 54-PC109091

Delafloxacin

CAS: 189279-58-1

Delafloxacin

Purity: ≥98%

Molecular weight: 440.76g/mol

Ref: 54-BUP13769

Delafloxacin

CAS: 189279-58-1

Formula: C₁₈H₁₂ClF₃N₄O₄

Color and Shape: Yellow Solid

Molecular weight: 440.76

Ref: 4Z-D-189001

Delafloxacin-d5

CAS: 189279-58-1

Formula: C₁₈H₇D₅ClF₃N₄O₄

Molecular weight: 445.79

Ref: 4Z-D-189002

Delafloxacin

CAS: 189279-58-1

Formula: C₁₈H₁₂ClF₃N₄O₄

Color and Shape: Neat

Molecular weight: 440.76

Ref: 04-C12117300

Delafloxacin

CAS: 189279-58-1

Formula: C₁₈H₁₂ClF₃N₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 440.76

Ref: 3B-D6143

Delafloxacin

CAS: 189279-58-1

Delafloxacin (WQ-3034, RX-3341, ABT-492) is a potent antibiotic for levofloxacin-resistant S. pneumoniae (MIC: 0.0078-0.125 μg/ml).

Formula: C₁₈H₁₂ClF₃N₄O₄

Purity: 99.76%

Color and Shape: Solid

Molecular weight: 440.76

Ref: TM-T4063

Delafloxacin - Bio-X ™

CAS: 189279-58-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₈H₁₂ClF₃N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 440.76 g/mol

Ref: 3D-BD300027

Delafloxacin

CAS: 189279-58-1

Delafloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating acute bacterial skin and skin structure infections.

Formula: C₁₈H₁₂ClF₃N₄O₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 440.76 g/mol

Ref: 3D-FA44045

Delafloxacin

Controlled Product

CAS: 189279-58-1

Applications Delafloxacin is a potent agent and broad-spectrum anionic fluoroquinolone against Streptococcus pneumoniae and diverse group of pathogens.
References Flamm, R. K., et al.: Antimicrob. Agents Chemother., 60, 6381-6385 (2016); Lepak, A. J., et al.: Antimicrob. Agents Chemother., 60, 4764-4769 (2016);

Formula: C₁₈H₁₂ClF₃N₄O₄

Color and Shape: Neat

Molecular weight: 440.76

Ref: TR-D231740