CAS 189388-22-5

Endomorphin-1

Description:

Endomorphin-1 is a naturally occurring peptide that functions as an endogenous opioid, primarily involved in pain modulation and the regulation of emotional responses. It is derived from proenkephalin and is known for its high affinity for the mu-opioid receptor, which plays a crucial role in analgesia and the reward pathway in the brain. Structurally, Endomorphin-1 consists of a sequence of amino acids, specifically Tyr-Pro-Trp-Phe-NH2, which contributes to its biological activity. This peptide exhibits potent analgesic effects, often compared to morphine, but with a reduced side effect profile, making it a subject of interest in pain management research. Additionally, Endomorphin-1 has been studied for its potential therapeutic applications in treating various conditions, including chronic pain and mood disorders. Its stability and bioavailability are important factors in its pharmacological potential, and ongoing research continues to explore its mechanisms of action and possible clinical uses.

Formula: C₃₄H₃₈N₆O₅

InChI: InChI=1/C34H38N6O5/c35-26(17-22-12-14-24(41)15-13-22)34(45)40-16-6-11-30(40)33(44)39-29(19-23-20-37-27-10-5-4-9-25(23)27)32(43)38-28(31(36)42)18-21-7-2-1-3-8-21/h1-5,7-10,12-15,20,26,28-30,37,41H,6,11,16-19,35H2,(H2,36,42)(H,38,43)(H,39,44)/t26-,28-,29-,30-/m0/s1

SMILES: c1ccc(cc1)C[C@@H](C(=N)O)N=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)O)N)O)O

Synonyms:

• Endomorphin-1 (Human, Bovine)
• Tyr-Pro-Trp-Phe-Nh2
• Ypwf-Nh2
• (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide
• L-tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide

Endomorphin-1

CAS: 189388-22-5

Endomorphin-1 (YPWF-amide) is the most potent and selective endogenous agonist for the mu-opiate receptor so far described (Ki = 360 pM; 4’000- and 15’000-fold preference over the delta and kappa receptors). It may be a natural ligand for this receptor. Endomorphin-1 has been shown to inhibit the aggregation of Aβ in vitro and is effective in vivo.

Formula: C₃₄H₃₈N₆O₅

Purity: 99.2%

Color and Shape: White Powder

Molecular weight: 610.71

Ref: 01-4027684

L-PHENYLALANINAMIDE, L-TYROSYL-L-PROLYL-L-TRYPTOPHYL-

CAS: 189388-22-5

Formula: C₃₄H₃₈N₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 610.7027

Ref: IN-DA002DMW

Endomorphin 1

CAS: 189388-22-5

Endomorphin 1

Purity: ≥95%

Molecular weight: 610.7g/mol

Ref: 54-BUP06715

Endomorphin 1

CAS: 189388-22-5

Formula: C₃₄H₃₈N₆O₅

Molecular weight: 610.70

Ref: 7W-GK3209

Endomorphin 1

CAS: 189388-22-5

Endomorphin 1 is a high affinity and selective agonist of the μ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM).

Formula: C₃₄H₃₈N₆O₅

Purity: 95.92%

Color and Shape: Solid (Solid Powder )

Molecular weight: 610.7

Ref: TM-TQ0267