CAS 18944-28-0

3-KETO-DIHYDROSPHINGOSINE HCL

Description:

3-Keto-dihydrosphingosine hydrochloride, with the CAS number 18944-28-0, is a sphingolipid metabolite that plays a significant role in cellular signaling and membrane structure. This compound features a long-chain amino alcohol backbone, characteristic of sphingolipids, and contains a keto group at the third carbon position, which distinguishes it from other sphingoid bases. As a hydrochloride salt, it is typically more soluble in water, facilitating its use in biological and biochemical studies. The substance is often utilized in research related to cell biology, particularly in studies investigating sphingolipid metabolism, apoptosis, and cellular stress responses. Its structural properties allow it to interact with various cellular components, influencing signaling pathways and cellular functions. Additionally, 3-keto-dihydrosphingosine may serve as a precursor for the synthesis of more complex sphingolipids, highlighting its importance in lipid biochemistry. Safety and handling precautions should be observed, as with all chemical substances, particularly in laboratory settings.

Synonyms:

• 3-Keto-Sphinganine Hydrochloride
• 3-Keto-Dihydrosphingosine Hydrochloride

3-Octadecanone, 2-amino-1-hydroxy-, (2S)-

CAS: 18944-28-0

Formula: C₁₈H₃₇NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 299.4919

Ref: IN-DA002DOE

(2S)-2-Amino-1-hydroxyoctadecan-3-one

CAS: 18944-28-0

(2S)-2-Amino-1-hydroxyoctadecan-3-one

Purity: 98%

Ref: 54-OR1076487

3-keto-Dihydrosphingosine HCl-salt

CAS: 18944-28-0

Formula: C18H37NO2

Purity: >98%

Color and Shape: Solid

Molecular weight: 299.49

Ref: 48-56-1312

3-Ketodihydrosphingosine

Controlled Product

CAS: 18944-28-0

Applications 3-Ketodihydrosphingosine is derived from N-Boc-L-Serine (B667355), which is an N-Boc-protected form of L-Serine (S270975). L-Serine is a non-essential amino acid that is required for the synthesis of sphinogolipids and phosphatidylserine, compounds that are important for central nervous system neuronal survival. L-Serine is also important in intermediary metabolism in eukaryotic cells.
References de Koning, T., et al.: Biochem. J., 371, 653 (2003); Furuya, S.: Asia Pac. J. Clin. Nutr., 17, 312 (2008); Hirabayashi, Y. & Furuya, S.: Prog. Lipid. Res., 47, 188 (2008)

Formula: C₁₈H₃₇NO₂

Color and Shape: Neat

Molecular weight: 299.49

Ref: TR-K188525

3-Keto-dihydrosphingosine

CAS: 18944-28-0

3-Keto-dihydrosphingosine is a metabolite of sphingolipids, which are long chain fatty acids that are found in cell membranes. It is also an active form of the enzyme serine palmitoyltransferase, which catalyzes the final step of sphingolipid synthesis. 3-Keto-dihydrosphingosine has been shown to have antimicrobial activity against Gram-positive bacteria and fungi. The optimum concentration for this compound is at 10 mM, and it inhibits the growth of bacteria by inhibiting enzyme activities involved in the biosynthesis of lipids and proteins. 3-Keto-dihydrosphingosine may be used as an important substrate for drug development to treat infectious diseases such as tuberculosis or leprosy.

Formula: C₁₈H₃₇NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 299.5 g/mol

Ref: 3D-TAA94428

3-Ketodihydrosphingosine-d13

Controlled Product

CAS: 18944-28-0

Formula: C₁₈D₁₃H₂₄NO₂

Color and Shape: Neat

Molecular weight: 312.572

Ref: TR-K188527