CAS 189450-19-9

CORTISTATIN-17 (HUMAN)

Description:

Cortistatin-17 is a neuropeptide that is derived from the cortistatin family, which is known for its role in modulating various physiological processes, particularly in the central nervous system. This peptide is characterized by its ability to interact with specific receptors, influencing neurotransmission and potentially impacting sleep regulation, stress response, and neuroprotection. Cortistatin-17 exhibits structural similarities to other neuropeptides, such as somatostatin, but has distinct biological activities. Its sequence and conformation allow it to bind to receptors with high specificity, leading to diverse effects on cellular signaling pathways. The CAS number 189450-19-9 uniquely identifies this compound in chemical databases, facilitating research and development in pharmacology and neuroscience. Studies have suggested that cortistatin-17 may have therapeutic potential in treating conditions related to sleep disorders and neurodegenerative diseases, although further research is needed to fully elucidate its mechanisms of action and clinical applications. Overall, cortistatin-17 represents an intriguing area of study within neurobiology and peptide chemistry.

Formula: C₉₆H₁₄₁N₂₇O₂₄S₃

Synonyms:

• Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys
• H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-Oh
• H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH, (Disulfide bond)
• M.W. 2151.53 C96H139N27O24S3
• Cortistatin-17 (human) trifluoroacetate salt
• Cortistatin-17 (human) trifluoroacetate salt H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH trifluoroacetate salt (Disulfide bond)
• Cortistatin-17 (human) (H-5536.0500)
• ASP-ARG-MET-PRO-CYS-ARG-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS (DISULFIDE BRIDGE CYS5-CYS16)
• CORTISTATIN-17 (HUMAN)

Cortistatin-17 (human) trifluoroacetate salt

CAS: 189450-19-9

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Formula: C₉₆H₁₃₉N₂₇O₂₄S₃

Purity: Min. 95%

Molecular weight: 2,151.5 g/mol

Ref: 3D-FC109533

Cortistatin-17 (human)

CAS: 189450-19-9

Cortistatin-17 shows structural similarities to somatostatin. The peptide binds to all somatostatin receptor subtypes (SSTR) in a similar way as the rat cortistatin. Its inhibitory effects on forskolin-stimulated cAMP production in chinese hamster ovary cells expressing SSTR2-5 are dose dependent but slightly less efficient than that of somatostatin-14. Like the rat cortistatin it has an effect on sleep and wakefulness pattern in rat. It decreases the light slow wave sleep (SWS1) and increases the deep slow wave sleep (SWS2) in a dose dependent manner. Administration of the peptide causes a temporary flattening of cortical and hippocampal electroencephalograms.

Formula: C₉₆H₁₃₉N₂₇O₂₄S₃

Purity: 96.1%

Color and Shape: White Powder

Molecular weight: 2151.53

Ref: 01-4037520