CAS 189453-10-9: Epothilone D

Description: Epothilone D is a natural product and a member of the epothilone family, which are macrocyclic compounds known for their ability to stabilize microtubules, similar to the mechanism of action of taxanes like paclitaxel. It is characterized by its complex structure, which includes a 16-membered macrolide ring and multiple stereocenters, contributing to its biological activity. Epothilone D exhibits potent antitumor properties, making it a subject of interest in cancer research and drug development. It has shown efficacy against various cancer cell lines and is being investigated for its potential use in treating resistant tumors. The compound is soluble in organic solvents and has a relatively low solubility in water, which can influence its bioavailability and formulation in therapeutic applications. Its mechanism involves binding to the β-tubulin subunit of microtubules, leading to cell cycle arrest and apoptosis in cancer cells. Overall, Epothilone D represents a promising avenue for developing new cancer therapies, particularly for tumors that are resistant to conventional treatments.

Formula: C₂₇H₄₁NO₅S

InChI: InChI=1/C27H41NO5S/c1-16-9-8-10-17(2)25(31)19(4)26(32)27(6,7)23(29)14-24(30)33-22(12-11-16)18(3)13-21-15-34-20(5)28-21/h11,13,15,17,19,22-23,25,29,31H,8-10,12,14H2,1-7H3/b16-11-,18-13+/t17-,19+,22?,23-,25-/m0/s1

InChI key: InChIKey=XOZIUKBZLSUILX-GIQCAXHBSA-N

SMILES: O=C1OC(C(=CC=2N=C(SC2)C)C)CC=C(C)CCCC(C)C(O)C(C(=O)C(C)(C)C(O)C1)C

Synonyms:

• (-)-Desoxyepothilone B
• (4R,7S,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]oxacyclohexadec-13-ene-2,6-dione
• (4S,7R,8S,9S,13Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxacyclohexadec-13-ene-2,6-dione
• (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione
• 12,13-Deoxyepothilone B
• 12,13-Desoxyepothilone B
• Epo D
• Epothilone D
• Kos 862
• NSC 703147
• Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl -16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4S-(4R*,7S,8R*,9R*,1 3Z,16R*(E)))-
• Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, [4S-[4R*,7S*,8R*,9R*,13Z,16R*(E)]]-
• Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-

Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-

CAS: 189453-10-9

• Formula: C₂₇H₄₁NO₅S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 491.6831

Epothilone D

CAS: 189453-10-9

• Formula: C₂₇H₄₁NO₅S
• Molecular weight: 491.69

Epothilone D (synthetic)

CAS: 189453-10-9

Applications Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to …

• Formula: C₂₆H₃₉NO₅S
• Color and Shape: Neat
• Molecular weight: 477.66

Epothilone D (synthetic)

CAS: 189453-10-9

Microtubule stabilizer; natural polyketide compound; antineoplastic

• Formula: C₂₇H₄₁NO₅S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 491.69 g/mol

Epothilone D

CAS: 189453-10-9

Epothilone D (KOS 862) is a potent microtubule stabilizer.

• Formula: C₂₇H₄₁NO₅S
• Color and Shape: Solid
• Molecular weight: 491.68