CAS 1895916-22-9

L-Alanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-, 2,5-dioxo-1-pyrrolidinyl ester

Description:

L-Alanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-, 2,5-dioxo-1-pyrrolidinyl ester, identified by CAS number 1895916-22-9, is a synthetic compound that features a complex structure incorporating amino acids and a pyrrolidine moiety. This substance is characterized by its potential biological activity, particularly in the context of peptide synthesis and drug development. The presence of L-alanine and L-valine suggests that it may exhibit properties related to protein synthesis or modulation of metabolic pathways. The pyrrolidine ring contributes to its stability and may influence its interaction with biological targets. Additionally, the compound's ester functionality indicates potential for hydrolysis, which could affect its bioavailability and pharmacokinetics. Overall, this compound represents a class of molecules that may have applications in medicinal chemistry, particularly in the design of therapeutics targeting specific biological processes. Further studies would be necessary to elucidate its precise mechanisms of action and potential therapeutic uses.

Formula: C₂₂H₃₀N₄O₈

Synonyms:

• MC-Val-Ala-NHS ester
• L-Alanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-, 2,5-dioxo-1-pyrrolidinyl ester

MC-val-ala-nhs ester

CAS: 1895916-22-9

MC-Val-Ala-NHS ester is a cleavable ADC linker featuring maleimide and NHS ester groups. The Val-Ala linker is susceptible to cleavage by cathepsin B. The maleimide group can react with thiol groups, as can the MC component. The NHS ester reacts specifically and efficiently with amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or mildly alkaline conditions, forming covalent bonds. Reagent grade, intended for research use only.

Formula: C₂₂H₃₀N₄O₈

Color and Shape: Solid

Molecular weight: 478.496

Ref: TM-TYD-02069