CAS 189691-06-3

PT-141

Description:

PT-141, also known as Bremelanotide, is a synthetic peptide that acts as a melanocortin receptor agonist. It is primarily recognized for its potential use in treating sexual dysfunction, particularly in women experiencing hypoactive sexual desire disorder. The substance is derived from a naturally occurring peptide and is designed to stimulate sexual arousal by activating specific receptors in the brain. PT-141 is distinct from traditional erectile dysfunction medications, as it does not primarily work on the vascular system but rather influences the central nervous system. Its mechanism involves the activation of melanocortin receptors, which play a role in various physiological functions, including appetite regulation and sexual behavior. PT-141 is administered via subcutaneous injection and has been studied for its efficacy and safety profile. While it shows promise, further research is ongoing to fully understand its effects and potential applications in sexual health. As with any medication, it is essential to consult healthcare professionals regarding its use and potential side effects.

Formula: C₅₀H₆₈N₁₄O₁₀

InChI: InChI=1/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41?/m0/s1

Synonyms:

• Bremelanotide
• Brmelanotice
• Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH
• (3S,6S,9R,12S,23S)-15-[(N-acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid
• Brmelanotide
• Pt141
• Bromelanotide

(3S,6S,9R,12S,15S,23S)-9-benzyl-6-(3-carbamimidamidopropyl)-15-[(2S)-2-acetamidohexanamido]-12-[(1H-imidazol-4-yl)methyl]-3-[(1H-indol-3-yl)methyl]-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid

CAS: 189691-06-3

Formula: C₅₀H₆₈N₁₄O₁₀

Purity: ≥97%

Molecular weight: 1025.1627

Ref: IN-DA002DWJ

Bremelanotide

CAS: 189691-06-3

Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R.

Formula: C₅₀H₆₈N₁₄O₁₀

Purity: 98%

Color and Shape: White Powder

Molecular weight: 1025.16

Ref: TM-T20467

Bremelanotide

CAS: 189691-06-3

Formula: C₅₀H₆₈N₁₄O₁₀

Molecular weight: 1025.18

Ref: 4Z-B-198001

Bremelanotide Acetate Hydrate

Controlled Product

CAS: 1607799-13-2, 189691-06-3

Stability Hygroscopic
Applications Bremelanotide is a melanocortin receptor agonist shown to improve female sexual function in females suffering from sexual dysfunction.
References Safarinejad, M. et al.: J. Sex. Med., 50, 887 (2008); Pfaus, J. et al.: J. Sex. Med., 4, 269 (2007);

Formula: C₅₂H₇₄N₁₄O₁₃

Color and Shape: Neat

Molecular weight: 1103.23

Ref: TR-B677355

Bremelanotide

CAS: 189691-06-3

Bremelanotide is a synthetic cyclic peptide, classified as a melanocortin receptor agonist. It is derived from the analogs of the alpha-melanocyte-stimulating hormone (α-MSH), with its origins in melanocortin system research. This product acts primarily through the activation of melanocortin 4 receptor (MC4R) pathways in the central nervous system.Bremelanotide exerts its physiological effects by stimulating these receptors, leading to increased neural signals related to sexual arousal and desire. The melanocortin receptors, especially MC4R, play a significant role in modulating various neural networks involved in sexual function.This compound is utilized primarily for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. By enhancing sexual desire and arousal, Bremelanotide provides a therapeutic option for individuals experiencing clinically significant distress related to low sexual desire. Its application in clinical settings highlights the potential of melanocortin pathways as therapeutic targets beyond their established roles in pigmentary and energy balance modulation.

Formula: C₅₀H₆₈N₁₄O₁₀

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,025.16 g/mol

Ref: 3D-FB159119