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CAS 1898232-70-6

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  • SC428
    Targetmol
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    SC428

    CAS:
    <p>SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.</p>
    Formula:C15H10F3N3OS
    Color and Shape:Solid
    Molecular weight:337.32

    Ref: TM-T200348