CAS 189950-66-1

AC-DEVD-PNA

Description:

AC-DEVD-PNA, with the CAS number 189950-66-1, is a synthetic peptide substrate commonly used in biochemical research, particularly in the study of caspases, which are a family of cysteine proteases involved in apoptosis (programmed cell death). This compound is characterized by its specific sequence that includes the amino acids aspartic acid (D) and valine (V), which are crucial for caspase recognition and cleavage. The "AC" prefix indicates the presence of an acetyl group, enhancing the peptide's stability and solubility. The "PNA" suffix suggests that the peptide is linked to a peptide nucleic acid, which can facilitate the study of interactions between peptides and nucleic acids. AC-DEVD-PNA is typically utilized in assays to monitor caspase activity, making it valuable in cancer research and studies of cell death mechanisms. Its specificity for caspase-3 and related enzymes allows researchers to investigate the role of these proteases in various physiological and pathological processes.

Formula: C₂₆H₃₄N₆O₁₃

Synonyms:

• Caspase 3 (Apopain) Substrate 1, Chromogenic
• Caspase-3 Substrate Viii, Water-Soluble, Colorimetric
• Caspase 3/Cpp32 Chromogenic Substrate
• Caspase-3 Substrate (Chromogenic)
• Caspase-3 Substrate I, Colorimetric
• Chromogenic Caspase 3 Substrate Ac-Devd-Pna
• Ac-Asp-Glu-Val-Asp-Paranitroanilide
• Ac-Asp-Glu-Val-Asp-Pna

L-Asparagine, N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)- (9CI)

CAS: 189950-66-1

Formula: C₂₆H₃₄N₆O₁₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 638.5806

Ref: IN-DA002E6P

Ac-DEVD-pNA

CAS: 189950-66-1

Ac-DEVD-pNA

Purity: ≥98%

Molecular weight: 638.58g/mol

Ref: 54-BUP09767

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

CAS: 189950-66-1

Formula: C₂₆H₃₄N₆O₁₃

Molecular weight: 638.58

Ref: 7W-GK4280

Ac-DEVD-pNA

CAS: 189950-66-1

Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.

Formula: C₂₆H₃₄N₆O₁₃

Purity: >99.99%

Color and Shape: White

Molecular weight: 638.58

Ref: TM-T7816

Ac-Asp-Glu-Val-Asp-pNA

CAS: 189950-66-1

Ac-Asp-Glu-Val-Asp-pNA is a peptide that is derived from the human tumor necrosis factor (TNF) precursor protein. It has been shown to inhibit the growth of tumor cells in vitro by inducing apoptosis. Ac-Asp-Glu-Val-Asp-pNA binds to and activates caspase 3, which leads to cleavage of the proapoptotic protein Bid into Bax and Bak, leading to mitochondrial membrane potential collapse and cell death. The peptide also inhibits DNA synthesis in HL60 cells and hemocytes. Ac-Asp-Glu-Val-Asp-pNA also inhibits proliferation of K562 cells through proteolytic degradation of the antiapoptotic protein Bcl2L11.

Formula: C₂₆H₃₄N₆O₁₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 638.58 g/mol

Ref: 3D-FA110798

N-Acetyl-L-a-aspartyl-L-a-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine xTFA Salt

Controlled Product

CAS: 189950-66-1

Stability Hygroscopic
Applications N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine TFA Salt is an para-nitro aniline chromophore cleaved by caspase.

Formula: C₂₆H₃₄N₆O₁₃•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 638.5811402

Ref: TR-A168315