CAS 190383-13-2

H-Ser-Leu-Ile-Gly-Lys-Val-NH2

Description:

The chemical substance identified as H-Ser-Leu-Ile-Gly-Lys-Val-NH2, with the CAS number 190383-13-2, is a peptide composed of a sequence of amino acids. This peptide features a C-terminal amide group, which enhances its stability and bioactivity compared to its carboxylic acid counterpart. The sequence includes serine (Ser), leucine (Leu), isoleucine (Ile), glycine (Gly), lysine (Lys), and valine (Val), which contribute to its unique properties and potential biological functions. Peptides like this one can exhibit various characteristics such as solubility in water, specific binding affinities to receptors, and potential roles in signaling pathways or as therapeutic agents. The presence of lysine, a positively charged amino acid, may influence the peptide's interaction with negatively charged biological molecules. Overall, the structure and composition of H-Ser-Leu-Ile-Gly-Lys-Val-NH2 suggest it may have applications in biochemistry and pharmacology, particularly in the development of peptide-based drugs or as research tools in studying protein interactions.

Formula: C₂₈H₅₄N₈O₇

Synonyms:

• Protease-Activated Receptor-2 Agonist, Amide
• Proteinase Activated Receptor 2 (1-6) Amide (Human)
• Proteinase Activated Receptor 2 Agonist Peptide Sligkv Amide, Human
• Ser-Leu-Ile-Gly-Lys-Val-Amide
• Ser-Leu-Ile-Gly-Lys-Val-Nh2
• Sligkvamide
• Sligkv-Nh2
• Par-2 Agonist Peptide (Sligkv) Amide, Human

PAR-2 (1-6) amide (human)

CAS: 190383-13-2

SLIGKV-amide, which corresponds to the tethered ligand sequence of human PAR-2 (protease activated receptor 2), can be used to investigate receptor functions.

Formula: C₂₈H₅₄N₈O₇

Purity: > 98%

Color and Shape: White Lyophilisate

Molecular weight: 614.79

Ref: 01-4029152

Protease-Activated Receptor-2, amide

CAS: 190383-13-2

Protease-Activated Receptor-2, amide

Purity: ≥98%

Molecular weight: 614.78g/mol

Ref: 54-BUP02117

Ser-Leu-Ile-Gly-Lys-Val-amide

CAS: 190383-13-2

Formula: C₂₈H₅₄N₈O₇

Molecular weight: 614.78

Ref: 7W-GK4405

Protease-Activated Receptor-2, amide

CAS: 190383-13-2

Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)

Formula: C₂₈H₅₄N₈O₇

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 614.78

Ref: TM-T7513

H-Ser-Leu-Ile-Gly-Lys-Val-NH2

CAS: 190383-13-2

H-Ser-Leu-Ile-Gly-Lys-Val-NH2 is a synthetic peptide that is a cyclase inhibitor. It binds to the receptor for neurokinin 1, which has been shown to inhibit lacrimal gland function in rats. The compound also inhibits the synthesis of epidermal growth factor and has been shown to have anti-inflammatory effects in mouse models. H-Ser-Leu-Ile-Gly-Lys-Val-NH2 has also been shown to inhibit protease activity in rat prostate cells and can be used as a chemical inhibitor for proteases.

Formula: C₂₅H₅₄N₈O₇

Purity: Min. 95%

Molecular weight: 614.79 g/mol

Ref: 3D-PAR-3889-PI

PAR-2 (1-6) amide (human) trifluoroacetate salt

CAS: 190383-13-2

PAR-2 (1-6) amide (human) trifluoroacetate salt H-Ser-Leu-Ile-Gly-Lys-Val-NH2 trifluoroacetate salt is a protease inhibitor that inhibits the activity of PAR2, a protein receptor. PAR2 is implicated in cancer and inflammation. It has been shown to inhibit growth factor signaling, as well as activate toll-like receptor 4 and other inflammatory pathways. PAR2 inhibition has also been studied in vivo and found to be effective in treating wild type mice with melanoma cells. In vitro studies have shown that PAR2 inhibition by PAR 2 (1-6) amide (human) trifluoroacetate salt H-Ser-Leu-Ile-Gly-Lys-Val NH2 trifluoroacetate salt blocks the production of tumour necrosis factor alpha and interleukin 6.

Formula: C₂₈H₅₄N₈O₇

Purity: Min. 95%

Molecular weight: 614.78 g/mol

Ref: 3D-FP109317