CAS 190648-49-8

(2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-4-oxo-4-piperidin-1-yl-2-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]butanamide

Description:

The chemical substance with the name "(2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-4-oxo-4-piperidin-1-yl-2-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]butanamide" and CAS number "190648-49-8" is a complex organic compound characterized by its multi-functional groups and stereochemistry. It features a piperidine ring, which contributes to its potential biological activity, and a butanamide backbone that may influence its solubility and reactivity. The presence of a hydroxyl group suggests potential for hydrogen bonding, which can enhance interactions with biological targets. Additionally, the imidazolidinone moiety indicates possible applications in medicinal chemistry, particularly in drug design. The cyclopentylmethyl group may provide steric hindrance, affecting the compound's binding affinity and selectivity. Overall, this compound's structural complexity and functional diversity suggest it may exhibit interesting pharmacological properties, warranting further investigation in the context of drug development and therapeutic applications.

Formula: C₂₂H₃₆N₄O₅

InChI: InChI=1S/C22H36N4O5/c1-22(2)20(29)26(21(30)24(22)3)14-17(18(27)23-31)16(13-15-9-5-6-10-15)19(28)25-11-7-4-8-12-25/h15-17,31H,4-14H2,1-3H3,(H,23,27)/t16-,17+/m1/s1

InChI key: InChIKey=GFUITADOEPNRML-SJORKVTESA-N

SMILES: [C@@H]([C@H](CN1C(=O)C(C)(C)N(C)C1=O)C(NO)=O)(C(=O)N2CCCCC2)CC3CCCC3

Synonyms:

• (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
• 1-Piperidinebutanamide, beta-(cyclopentylmethyl)-N-hydroxy-gamma-oxo-alpha-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-, (alphaR,betaR)-
• 1-Piperidinebutanamide, β-(cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-, (αR,βR)-
• 1-Piperidinebutanamide, β-(cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-, [R-(R*,R*)]-
• Cipemastat
• Ro 32-3555
• Ro 32-3555/000
• Trocade
• (2R,3R)-3-(Cyclopentylmethyl)-N-hydroxy-4-oxo-4-(piperidin-1-yl)-2-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]butanamide

1-Piperidinebutanamide, β-(cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-, (αR,βR)-

CAS: 190648-49-8

Formula: C₂₂H₃₆N₄O₅

Color and Shape: Solid

Molecular weight: 436.5450

Ref: IN-DA002EPT

Ro 32-3555

Controlled Product

CAS: 190648-49-8

Applications Ro 32-3555 is an orally active collagenase inhibitor that prevents cartilage breakdown. It is used for the treatment of arthritis.
References Lewis, E., et al.: Br. J. Pharmacol., 121, 540 (1997); Hemmings, F., et al.: Rheumatology, 40, 537 (2001);

Formula: C₂₂H₃₆N₄O₅

Color and Shape: Neat

Molecular weight: 436.55

Ref: TR-R700905

Cipemastat

CAS: 190648-49-8

Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).

Formula: C₂₂H₃₆N₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 436.55

Ref: TM-T10817