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CAS 190730-42-8

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Bepotastine Besilate

Description:
Bepotastine besilate is an antihistamine used primarily for the treatment of allergic conjunctivitis. It functions as a selective H1 receptor antagonist, effectively alleviating symptoms such as itching and redness in the eyes. The substance is characterized by its ability to inhibit the release of histamine, a key mediator in allergic reactions. Bepotastine besilate is typically administered as an ophthalmic solution, allowing for localized treatment with minimal systemic absorption. Its chemical structure includes a benzhydryl moiety, contributing to its pharmacological properties. The compound is known for its relatively low side effect profile compared to other antihistamines, making it suitable for long-term use in managing allergic symptoms. Additionally, it is stable under normal storage conditions and has a favorable solubility profile, which enhances its formulation in eye drop preparations. Overall, bepotastine besilate represents a valuable option in the therapeutic arsenal for managing allergic eye conditions.
Formula:C27H31ClN2O6S
InChI:InChI=1/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26;7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26);1-5H,(H,7,8,9)/t21-;/m1./s1
SMILES:c1ccnc(c1)[C@@H](c1ccc(cc1)Cl)OC1CCN(CCCC(=O)O)CC1.c1ccc(cc1)S(=O)(=O)O
Synonyms:
  • 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate
  • 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate
  • 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid
  • Bepotastine besylate
  • 4-{4-[(S)-(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate (1:1)
  • 4-{4-[(R)-(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate (1:1)
  • 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-, monobenzenesulfonate
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