CAS 190786-44-8

Bepotastine besilate

Description:

Bepotastine besilate is an antihistamine medication primarily used for the treatment of allergic conjunctivitis and other allergic conditions. It functions as a selective H1 receptor antagonist, effectively blocking the action of histamine, a compound involved in allergic responses. This substance is characterized by its ability to alleviate symptoms such as itching, redness, and swelling associated with allergies. Bepotastine besilate is typically administered as an ophthalmic solution, allowing for direct application to the eyes, which enhances its efficacy and minimizes systemic side effects. The compound is known for its rapid onset of action and relatively favorable safety profile, making it a preferred choice in allergy management. Additionally, it is soluble in water, which facilitates its formulation in liquid dosage forms. As with any medication, potential side effects may include local irritation or discomfort, but these are generally mild. Overall, bepotastine besilate represents a targeted approach to managing allergic symptoms, particularly in the ocular region.

Formula: C₂₁H₂₅ClN₂O₃·C₆H₆O₃S

InChI: InChI=1S/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26;7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26);1-5H,(H,7,8,9)/t21-;/m0./s1

InChI key: InChIKey=UDGHXQPQKQPSBB-BOXHHOBZSA-N

SMILES: [C@H](OC1CCN(CCCC(O)=O)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=N3.S(=O)(=O)(O)C1=CC=CC=C1

Synonyms:

• 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate
• Talion
• 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1)
• Bepotastine besilate
• 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate

1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1)

CAS: 190786-44-8

Formula: C₂₇H₃₁ClN₂O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 547.0628

Ref: IN-DA002ET1

Bepotastine besilate

CAS: 190786-44-8

Bepotastine besilate

Purity: 98%

Molecular weight: 547.07g/mol

Ref: 54-OR1030469

Bepotastine Besilate

CAS: 190786-44-8

Bepotastine Besilate

Purity: ≥98%

Molecular weight: 547.06g/mol

Ref: 54-BUP16859

Bepotastine Besylate

CAS: 190786-44-8

Formula: C₂₁H₂₅ClN₂O₃·C₆H₆O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 388.90 158.18

Ref: 4Z-B-503

Bepotastine Besilate

CAS: 190786-44-8

Bepotastine Besilate (TAU 284) is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).

Formula: C₂₁H₂₅ClN₂O₃·C₆H₆O₃S

Purity: 99.83% - 99.9%

Color and Shape: Brown Viscous Liquid

Molecular weight: 547.06

Ref: TM-T6405

Bepotastine-d6 Besylate

Controlled Product

CAS: 190786-44-8

Stability Hygroscopic
Applications Labelled Bepotastine. Bepotastine is a histamine H1 receptor anatagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).
References Kaminuma, O. et al.: Biol. Pharm. Bull., 21, 411 (1998); Kitaba, S. et al.: J. Allergy, No pp. given (2008); Lyseng-Williamson, K.A., Drugs, 70, 1579 (2010);

Formula: C₂₇H₂₅D₆ClN₂O₆S

Color and Shape: Off-White

Molecular weight: 553.1

Ref: TR-B317002

(S)-Bepotastine Besylate

Controlled Product

CAS: 190786-44-8

Stability Hygroscopic
Applications Bepotastine is a histamine H1 receptor antagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).
References Kaminuma, O. et al.: Biol. Pharm. Bull., 21, 411 (1998); Kitaba, S. et al.: J. Allergy, No pp. given (2008); Lyseng-Williamson, K.A., Drugs, 70, 1579 (2010);

Formula: C₂₁H₂₅ClN₂O₃·C₆H₆O₃S

Color and Shape: Neat

Molecular weight: 547.06

Ref: TR-B317000