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CAS 190791-29-8

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Lasofoxifene tartrate

Description:
Lasofoxifene tartrate is a selective estrogen receptor modulator (SERM) primarily investigated for its potential use in treating osteoporosis and breast cancer. As a SERM, it exhibits tissue-selective estrogenic activity, meaning it can mimic or block estrogen's effects in different tissues. This compound is known for its ability to promote bone density while minimizing the risk of estrogen-related side effects in breast and uterine tissues. Lasofoxifene tartrate is typically administered in a salt form, which enhances its solubility and bioavailability. The substance has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are crucial for determining its therapeutic efficacy and safety profile. Additionally, it has shown promise in reducing the risk of invasive breast cancer in postmenopausal women. Overall, Lasofoxifene tartrate represents a significant advancement in the development of targeted therapies for conditions influenced by estrogen.
Formula:C28H31NO2·C4H6O6
InChI:InChI=1S/C28H31NO2.C4H6O6/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29;5-1(3(7)8)2(6)4(9)10/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2;1-2,5-6H,(H,7,8)(H,9,10)/t26-,28+;1-,2-/m10/s1
InChI key:InChIKey=INEHJXCWEVNEDZ-LUDNRVPPSA-N
SMILES:OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1.[C@H]([C@@H](C(O)=O)O)(C(O)=O)O
Synonyms:
  • (-)-cis-5,6,7,8-Tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol D-tartrate (1:1) (salt)
  • (5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol 2,3-dihydroxybutanedioate (salt)
  • 2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-, (5R,6S)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1) (salt)
  • 2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-, (5R-cis)-, (S-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
  • 2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-, cis-(-)-, (S-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
  • 2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, (5R,6S)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1)
  • Cb 336156Eb
  • Cp 336156
  • Fablyn
  • Lasofoxifene tartrate
  • See more synonyms
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