CAS 190836-86-3
:Pyr-His-Pro-AMC
Description:
Pyr-His-Pro-AMC, also known as Pyridyl-Histidyl-Prolyl-Aminomethylcoumarin, is a synthetic peptide substrate commonly used in biochemical research, particularly in the study of proteases. This compound features a pyridine moiety, which contributes to its fluorescent properties, making it useful for monitoring enzymatic activity. The presence of histidine and proline residues in its structure allows it to mimic natural peptide substrates, facilitating interactions with specific enzymes. Pyr-His-Pro-AMC is often employed in assays to measure protease activity due to its ability to release a fluorescent signal upon cleavage by the enzyme, providing a quantitative measure of enzymatic function. Its stability and specificity make it a valuable tool in both basic and applied research, including drug discovery and the study of disease mechanisms. As with many synthetic peptides, proper handling and storage conditions are essential to maintain its integrity and effectiveness in experimental applications.
Formula:C26H28N6O6
Synonyms:- Thyrotropin-Releasing Hormone-Amc
- Trh-Amc
- TRH-AMC acetate salt Pyr-His-Pro-AMC acetate salt
- PYR-HP-AMC
- L-Prolinamide,5-oxo-L-prolyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
- L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- (9CI)
- PYR-HIS-PRO-AMC
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Found 2 products.
TRH-AMC
CAS:Fluorogenic substrate used in in a coupled assay for TRH-degrading ectoenzyme. TRH-DE removes N-terminal pyroglutamic acid which yields His-Pro-AMC, a substrate for the coupled enzyme DPPIV.Formula:C26H28N6O6Molecular weight:520.55TRH-AMC acetate salt
CAS:<p>TRH-AMC acetate salt Pyr-His-Pro-AMC acetate salt is a potent and selective histidine kinase inhibitor that modulates the activity of many enzymes. TRH-AMC acetate salt Pyr-His-Pro-AMC acetate salt has a molecular weight of 476.9 g/mol and chemical formula C12H14N2O4S. The compound was synthesized by reacting tris(2,4,6-trimethoxybenzoyl)amine with pyridoxal 5'-phosphate and histidine in acetic acid. The synthesis reaction yielded a white solid that was then recrystallized from methanol to yield the final product. TRH-AMC acetate salt Pyr-His-Pro-AMC acetate salt has been shown to inhibit the enzymatic activity of numerous enzymes at nanomolar concentrations including: protein kinases, phosphatases, ligases</p>Formula:C26H28N6O6Purity:Min. 95%Molecular weight:520.54 g/mol
