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CAS 191150-83-1

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Tipranavir disodium

Description:
Tipranavir disodium is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of protease inhibitors, which function by inhibiting the protease enzyme crucial for viral replication. This compound is characterized by its unique chemical structure, which includes a sulfonamide moiety, contributing to its antiviral activity. Tipranavir disodium is typically administered in combination with other antiretroviral agents to enhance its efficacy and reduce the likelihood of resistance development. The disodium salt form improves its solubility and bioavailability, facilitating better absorption in the body. It is important to note that tipranavir may have side effects, including gastrointestinal disturbances and potential liver toxicity, necessitating regular monitoring during treatment. Additionally, it is metabolized primarily by the liver, and its pharmacokinetics can be influenced by various factors, including concomitant medications and individual patient characteristics. Overall, tipranavir disodium represents a critical option in the therapeutic arsenal against HIV, particularly for treatment-experienced patients.
Formula:C31H33F3N2O5S
InChI:InChI=1/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)27(37)19-26(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)28-14-13-23(20-35-28)31(32,33)34/h5-14,18-20,25,29,36,38H,3-4,15-17H2,1-2H3/t25-,29?,30-/m0/s1
SMILES:CCC[C@]1(CCc2ccccc2)C(=O)C=C([C@@H](CC)c2cccc(c2)NS(=O)(=O)c2ccc(cn2)C(F)(F)F)C(O)O1
Synonyms:
  • Tipranavir disodium [USAN]
  • (R-(R*,R*))-N-(3-(1-(5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)-2-pyridinesulfonamide disodium salt
  • 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide, disodium salt
  • Pnu 140690E
  • Unii-9Ban2Xg1Zw
  • 2-Pyridinesulfonamide, N-(3-((1R)-1-((6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)-, disodium salt
  • 2-Pyridinesulfonamide, N-(3-(1-(5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)-, disodium salt, (R-(R*,R*))-
  • Tipranavir disodium
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