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CAS 1912445-55-6

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BMS-986195

Description:
BMS-986195, with the CAS number 1912445-55-6, is a chemical compound that has garnered attention in pharmaceutical research, particularly in the context of treating autoimmune diseases. It is classified as a selective inhibitor of the enzyme Janus kinase 1 (JAK1), which plays a crucial role in the signaling pathways of various cytokines involved in inflammatory responses. The compound's mechanism of action involves modulating immune responses, making it a potential therapeutic agent for conditions such as rheumatoid arthritis and other inflammatory disorders. BMS-986195 is characterized by its specific binding affinity to JAK1, which helps to minimize off-target effects associated with broader JAK inhibitors. In preclinical and clinical studies, it has demonstrated a favorable safety profile and efficacy in reducing disease activity. As with many investigational drugs, ongoing research is essential to fully understand its pharmacokinetics, pharmacodynamics, and long-term effects in diverse patient populations.
Formula:C20H23FN4O2
InChI:InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13-/m0/s1
InChI key:VJPPLCNBDLZIFG-ZDUSSCGKSA-N
SMILES:CC#CC(=O)N[C@H]1CCCN(C1)C2=C(C=C(C3=C2C(=C(N3)C)C)C(=O)N)F
Synonyms:
  • CPD1640
  • Branebrutinib (BMS-986195)
  • BMS-986195 USP/EP/BP
  • (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
  • BMS-986195; BMS986195; BMS986195
  • 1H-Indole-7-carboxamide, 5-fluoro-2,3-dimethyl-4-[(3S)-3-[(1-oxo-2-butyn-1-yl)amino]-1-piperidinyl]-
  • BMS-986195
Found 6 products.