CAS 19130-96-2

1-Deoxynojirimycin

Description:

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid derived from the mulberry tree, specifically Morus alba. It is classified as an iminosugar, which means it contains a nitrogen atom in place of a hydroxyl group in the sugar structure. DNJ is known for its ability to inhibit certain glycosidases, particularly α-glucosidases, which are enzymes involved in carbohydrate metabolism. This characteristic makes it of interest in the management of diabetes, as it can help regulate blood sugar levels by slowing down the absorption of carbohydrates in the intestine. Additionally, 1-Deoxynojirimycin exhibits potential antiviral properties, particularly against viruses like HIV and hepatitis C, by interfering with glycoprotein processing. The compound is typically found in various plant sources and can be extracted for use in research and potential therapeutic applications. Its safety profile and low toxicity make it a candidate for further studies in pharmacology and medicinal chemistry.

Formula: C₆H₁₃NO₄

InChI: InChI=1/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3?,4?,5-,6-/m1/s1

InChI key: InChIKey=LXBIFEVIBLOUGU-JGWLITMVSA-N

SMILES: C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1

Synonyms:

• (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol
• (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
• (2R,3R,4R,5S)-2-Hydroxymethyl-3,4,5-Trihydroxypiperidine
• 1,5-Dideoxy-1,5-Imino-D-Glucito
• 1,5-Dideoxy-1,5-Imino-D-Glucitol
• 1,5-Dideoxy-1,5-imino-<span class="text-smallcaps">D</span>-glucitol
• 1-Deoxy-Nojirimyci
• 1-Deoxynojirimicin
• 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-
• 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, [2R-(2α,3β,4α,5β)]-
• 5-Amino-1,5-Dideoxy-D-Glycopyranose
• 5-Amino-1,5-dideoxy-<span class="text-smallcaps">D</span>-glucopyranose
• 5-Dideoxy-5-Amino-D-Glucopyranos
• 5-Piperidinetriol(2R-(2Alpha,3Beta,4Alpha,5Beta))-2-(Hydroxymethyl)-4
• <span class="text-smallcaps">D</span>-1-Deoxynojirimycin
• <span class="text-smallcaps">D</span>-Glucitol, 1,5-dideoxy-1,5-imino-
• BAY-h 5595
• Deoxynojirimycin
• Duvoglustat
• Glucopyranose, 5-amino-1,5-dideoxy-, <span class="text-smallcaps">D</span>-
• Moranolin
• Moranoline
• Nojirimycin, 1-deoxy-
• Glucopyranose, 5-amino-1,5-dideoxy-, D-
• DEOXYNOJIRIMICIN
• 5-piperidinetriol,2-(hydroxymethyl)-,(2r-(2alpha,3beta,4alpha,5beta))-4
• bay-h5595
• (+)-1-DEOXYNOJIRIMYCIN
• 1-DEOXYNOJIRIMYCIN
• DNM

(+)-1-Deoxynojirimycin

CAS: 19130-96-2

An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancrea

Formula: C₆H₁₃NO₄

Color and Shape: White to off-white, Powder

Molecular weight: 163.17

Ref: 02-J62602

(2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 163.1717

Ref: IN-DA0039EZ

1-Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 163.17

Ref: 4Z-M-6411

1-Deoxynojirimycin

CAS: 19130-96-2

1-Deoxynojirimycin

Purity: ≥98%

Molecular weight: 163.17g/mol

Ref: 54-BUP13099

1-Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 163.17

Ref: 3B-D5612

1-Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Purity: 95%~99%

Molecular weight: 163.173

Ref: BP-BP0030

1-Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Color and Shape: Neat

Molecular weight: 163.17

Ref: 04-CA12148000

1-Deoxynojirimycin

CAS: 19130-96-2

1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.

Formula: C₆H₁₃NO₄

Purity: 99.65% - 99.98%

Color and Shape: White-Beige Solid Crystalline

Molecular weight: 163.17

Ref: TM-T3675

1-Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 163.17

Ref: 7W-GC2683

1-Deoxynojirimycin

CAS: 19130-96-2

1-Deoxynojirimycin

Formula: C₆H₁₃NO₄

Purity: >99%

Color and Shape: white to off-white powder

Molecular weight: 163.17171g/mol

Ref: 54-BICL4067

1-Deoxynojirimycin-d3

CAS: 19130-96-2

Formula: C₆H₁₀D₃NO₄

Molecular weight: 166.19

Ref: 4Z-M-6417

1-deoxynojirimycin

CAS: 19130-96-2

Natural alkaloid

Formula: C₆H₁₃NO₄

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 163.17

Ref: 5G-80421

Deoxynojirimycin

CAS: 19130-96-2

Stability Hygroscopic
Applications Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase.
References Eur. J. Biochem., 142, 85-90 (1984), Crit. Rev. Biochem., 16, 21-48 (1984), Biochem. Biochem. Acta. , 825, 95 (1985), Suhm, K., et al.: J. Biol. Chem., 267, 21671 (1992)

Formula: C₆H₁₃NO₄

Color and Shape: Neat

Molecular weight: 163.17

Ref: TR-D245000

1-Deoxynojirimycin

CAS: 19130-96-2

Glucose analog and potent inhibitor of α-glucosidases of class I and II. It interferes with N-linked glycosylation and oligosaccharide processing. The compound inhibits intestinal α-glucosidase and has protective effects against obesity-induced hepatic injury as well as mitochondrial dysfunction. It also has neuroprotective effects since it reduces senescence-related cognitive impairment, neuroinflammation and amyloid beta deposition in mice.

Formula: C₆H₁₃NO₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 163.17 g/mol

Ref: 3D-MD05255

1-Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 163.173

Ref: 10-M01692

Deoxynojirimycin

CAS: 19130-96-2

Formula: C₆H₁₃NO₄

Molecular weight: 163.2

Ref: ST-EA-CP-M20005