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CAS 191474-13-2

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5'-O-(4,4'-DIMETHOXYTRITYL)-2,3'-ANHYDROTHYMIDINE

Description:
5'-O-(4,4'-Dimethoxytrityl)-2,3'-anhydrothymidine is a modified nucleoside derivative of thymidine, characterized by the presence of a 4,4'-dimethoxytrityl (DMT) protecting group at the 5' position and an anhydro configuration at the 2' and 3' positions. This compound is typically used in the field of nucleic acid chemistry, particularly in the synthesis of oligonucleotides, due to its ability to protect the nucleoside during chemical reactions. The DMT group provides stability and solubility, facilitating the purification and handling of the nucleoside. The anhydro modification enhances the compound's resistance to nucleophilic attack, making it useful in various biochemical applications. Additionally, this compound is often employed in research and development for therapeutic oligonucleotides, as it can influence the stability and binding properties of the resulting nucleic acid sequences. Its unique structural features contribute to its functionality in synthetic and medicinal chemistry, making it a valuable tool in the development of nucleic acid-based technologies.
Formula:C31H30N2O6
InChI:InChI=1/C31H30N2O6/c1-20-18-33-28-17-26(39-30(33)32-29(20)34)27(38-28)19-37-31(21-7-5-4-6-8-21,22-9-13-24(35-2)14-10-22)23-11-15-25(36-3)16-12-23/h4-16,18,26-28H,17,19H2,1-3H3/t26-,27+,28+/m0/s1
Synonyms:
  • 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 3-[4,4'-dimethoxtrityl]-2,3-dihydro-8-methyl-, (2R,3R,5R)-
  • Anhydrothymidine-FLT-precursor
  • (2R,3R,5R)-3-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-2,3-dihydro-8-methyl-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one
  • 2,5-Methano-5H,9H-pyrimidol[2,1-b][1,5,3]dioxazepin-9-one,
  • 3-[4,4''-dimethoxtrityl]-2,3-dihydro-8-meth-yl,(2R,3R,5R)-
  • (2R,3R,5R)-3-[[Bis(4-methoxyphenyl)
  • phenylmethox-y]methyl]-2,3-dihydro-8-methyl-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one
  • (2R,3R,5R)-3-[[Bis(4-methoxyphenyl)
  • phenylmethox-y]methyl]-2,3-dihydro-8-methyl-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one
  • 2,5-Methano-5H,9H-pyrimidol[2,1-b][1,5,3]dioxazepin-9-one,
  • See more synonyms
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90
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