CAS 19171-19-8

Pomalidomide

Description:

Pomalidomide is an immunomodulatory drug primarily used in the treatment of multiple myeloma and certain other hematological malignancies. It belongs to a class of compounds known as thalidomide analogs, which exert their effects through various mechanisms, including modulation of the immune system and inhibition of tumor growth. The chemical formula of pomalidomide is C13H11N3O4S, and it features a unique structure that includes a phthalimide ring, a sulfonamide group, and an aromatic side chain. Pomalidomide is known for its ability to enhance T-cell and natural killer cell activity, as well as its anti-angiogenic properties, which help to inhibit the formation of new blood vessels that tumors require for growth. The drug is typically administered orally and has a relatively long half-life, allowing for convenient dosing schedules. However, it is associated with potential side effects, including hematological toxicities, and requires careful monitoring during treatment. Overall, pomalidomide represents a significant advancement in targeted cancer therapies.

Formula: C₁₃H₁₁N₃O₄

InChI: InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChI key: InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N

SMILES: O=C1N(C(=O)C=2C1=CC=CC2N)C3C(=O)NC(=O)CC3

Synonyms:

• 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
• 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
• 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
• 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
• 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
• 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
• 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
• Actimid
• Cc 4047
• Imnovid
• Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-

Pomalidomide

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow to Green powder to crystaline

Molecular weight: 273.25

Ref: 3B-P2074

4-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 273.2441

Ref: IN-DA002FFT

Pomalidomide

CAS: 19171-19-8

Pomalidomide

Purity: 98%

Molecular weight: 273.24g/mol

Ref: 54-BIPC1018

Pomalidomide

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Color and Shape: Yellow Solid

Molecular weight: 273.25

Ref: 4Z-P-178001

Pomalidomide

CAS: 19171-19-8

Pomalidomide

Purity: ≥98%

Molecular weight: 273.24g/mol

Ref: 54-BUP17160

Pomalidomide

CAS: 19171-19-8

Color and Shape: Neat

Ref: 86-MM3919.00

Pomalidomide

CAS: 19171-19-8

Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for CRBN. Cost-effective and quality-assured.

Formula: C₁₃H₁₁N₃O₄

Purity: 98.8% - >99.99%

Color and Shape: Solid

Molecular weight: 273.24

Ref: TM-T2384

Pomalidomide-d4

CAS: 19171-19-8

Formula: C₁₃H₇N₃O₄D₄

Color and Shape: White To Off-White Solid

Molecular weight: 277.27

Ref: 4Z-P-178012

Pomalidomide

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purity: ≥ 98.5%

Color and Shape: Yellow to green powder

Molecular weight: 273.24

Ref: 7W-GP0062

Pomalidomide

CAS: 19171-19-8

Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

Formula: C₁₃H₁₁N₃O₄

Color and Shape: Yellow

Molecular weight: 273.24

Ref: TR-P688200

Pomalidomide-d5

Controlled Product

CAS: 19171-19-8

Applications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

Formula: C₁₃D₅H₆N₃O₄

Color and Shape: Neat

Molecular weight: 278.27

Ref: TR-P688203

Pomalidomide - Bio-X ™

Controlled Product

CAS: 19171-19-8

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.
Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₃H₁₁N₃O₄

Purity: Min. 99 Area-%

Color and Shape: Powder

Molecular weight: 273.24 g/mol

Ref: 3D-BP164278

Pomalidomide

Controlled Product

CAS: 19171-19-8

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.

Formula: C₁₃H₁₁N₃O₄

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 273.24 g/mol

Ref: 3D-FA30210

4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 273.248

Ref: 10-F230365

Pomalidomide-d2 (Major)

Controlled Product

CAS: 19171-19-8

Formula: C₁₃D₂H₉N₃O₄

Color and Shape: Neat

Molecular weight: 275.26

Ref: TR-P688207