CAS 19171-19-8
:Pomalidomide
Description:
Pomalidomide is an immunomodulatory drug primarily used in the treatment of multiple myeloma and certain other hematological malignancies. It belongs to a class of compounds known as thalidomide analogs, which exert their effects through various mechanisms, including modulation of the immune system and inhibition of tumor growth. The chemical formula of pomalidomide is C13H11N3O4S, and it features a unique structure that includes a phthalimide ring, a sulfonamide group, and an aromatic side chain. Pomalidomide is known for its ability to enhance T-cell and natural killer cell activity, as well as its anti-angiogenic properties, which help to inhibit the formation of new blood vessels that tumors require for growth. The drug is typically administered orally and has a relatively long half-life, allowing for convenient dosing schedules. However, it is associated with potential side effects, including hematological toxicities, and requires careful monitoring during treatment. Overall, pomalidomide represents a significant advancement in targeted cancer therapies.
Formula:C13H11N3O4
InChI:InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key:InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N
SMILES:O=C1N(C(=O)C=2C1=CC=CC2N)C3C(=O)NC(=O)CC3
Synonyms:- 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
- 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
- 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
- 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
- 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
- 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
- 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
- Actimid
- Cc 4047
- Imnovid
- Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
- See more synonyms
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Found 15 products.
Pomalidomide
CAS:Formula:C13H11N3O4Purity:>98.0%(HPLC)Color and Shape:White to Yellow to Green powder to crystalineMolecular weight:273.254-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS:Formula:C13H11N3O4Purity:98%Color and Shape:SolidMolecular weight:273.2441Pomalidomide
CAS:Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for CRBN. Cost-effective and quality-assured.Formula:C13H11N3O4Purity:98.8% - >99.99%Color and Shape:SolidMolecular weight:273.24Pomalidomide-d4
CAS:Formula:C13H7N3O4D4Color and Shape:White To Off-White SolidMolecular weight:277.27Pomalidomide
CAS:Formula:C13H11N3O4Purity:≥ 98.5%Color and Shape:Yellow to green powderMolecular weight:273.24Pomalidomide
CAS:Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)Formula:C13H11N3O4Color and Shape:YellowMolecular weight:273.24Pomalidomide - Bio-X ™
CAS:Controlled ProductPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies. Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C13H11N3O4Purity:Min. 99 Area-%Color and Shape:PowderMolecular weight:273.24 g/molPomalidomide
CAS:Controlled ProductPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.Formula:C13H11N3O4Purity:Min. 98 Area-%Color and Shape:Yellow PowderMolecular weight:273.24 g/mol4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:Formula:C13H11N3O4Purity:98%Color and Shape:SolidMolecular weight:273.248Pomalidomide-d5
CAS:Controlled ProductApplications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)Formula:C13D5H6N3O4Color and Shape:NeatMolecular weight:278.27Pomalidomide-d2 (Major)
CAS:Controlled ProductFormula:C13D2H9N3O4Color and Shape:NeatMolecular weight:275.26
