CAS 1917306-14-9

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

Description:

2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- is a complex organic compound characterized by its thiazole and amide functional groups, which contribute to its biological activity. The presence of multiple halogen substituents, particularly the dichloro and trifluoromethyl groups, enhances its lipophilicity and may influence its interaction with biological targets. The compound also features a pyrrolidine moiety, which can affect its pharmacokinetic properties, such as absorption and metabolism. Its structural complexity suggests potential applications in medicinal chemistry, possibly as a pharmaceutical agent. The hydroxyl group indicates potential for hydrogen bonding, which may enhance solubility in polar solvents. Overall, this compound's unique combination of functional groups and substituents may confer specific biological activities, making it a subject of interest for further research in drug development and related fields.

Formula: C₂₃H₂₃Cl₂F₆N₃O₄S

Synonyms:

• 4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
• tert-butyl (3R
• 2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

JNJ-61803534

CAS: 1917306-14-9

JNJ-61803534: RORγt inverse agonist, IC50=9.6 nM, oral, anti-inflammatory, reduces IL-17A in T cells.

Formula: C₂₃H₂₃Cl₂F₆N₃O₄S

Color and Shape: Solid

Molecular weight: 622.41

Ref: TM-T70065