CAS 19216-56-9

Prazosin

Description:

Prazosin is a selective alpha-1 adrenergic antagonist primarily used in the treatment of hypertension and symptoms of benign prostatic hyperplasia. It works by blocking alpha-1 receptors on vascular smooth muscle, leading to vasodilation and a decrease in blood pressure. Prazosin is typically administered orally and has a relatively short half-life, necessitating multiple doses throughout the day for sustained effect. The compound is known for its ability to reduce peripheral resistance and improve urinary flow in patients with prostate enlargement. Additionally, it has been studied for its potential benefits in treating post-traumatic stress disorder (PTSD) due to its effects on reducing nightmares and improving sleep quality. Prazosin is generally well-tolerated, though it may cause side effects such as dizziness, headache, and orthostatic hypotension, particularly upon initiation of therapy. Its chemical structure includes a quinazoline ring, contributing to its pharmacological properties. As with any medication, it is essential for patients to consult healthcare professionals for appropriate dosing and monitoring.

Formula: C₁₉H₂₁N₅O₄

InChI: InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)

InChI key: InChIKey=IENZQIKPVFGBNW-UHFFFAOYSA-N

SMILES: NC=1C2=C(N=C(N1)N3CCN(C(=O)C4=CC=CO4)CC3)C=C(OC)C(OC)=C2

Synonyms:

• 2-[4-(2-Furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
• 2-[4-(Furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
• 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone
• Furazosin
• Lentopres
• Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-
• Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-
• Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-
• Prazosina
• Prazosine
• [4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)Piperazin-1-Yl](Furan-2-Yl)Methanone
• [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanylmethanone

Prazosin Hydrochloride

CAS: 19216-56-9, 19237-84-4

Formula: C₁₉H₂₁N₅O₄·HCl

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 419.87

Ref: 3B-P0938

2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine

CAS: 19216-56-9

Formula: C₁₉H₂₁N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.4011

Ref: IN-DA002FOM

Prazosin

CAS: 19216-56-9

Prazosin

Purity: ≥98%

Molecular weight: 383.4g/mol

Ref: 54-BUP06884

(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone hydrochloride salt

CAS: 19216-56-9

Formula: C₁₉H₂₁N₅O₄

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 383.408

Ref: 10-F242509

Prazosin

CAS: 19216-56-9

Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.

Formula: C₁₉H₂₁N₅O₄

Purity: 99.86%

Color and Shape: White To Tan Powder Solid

Molecular weight: 383.4

Ref: TM-T22406

Prazosin

CAS: 19216-56-9

Applications Prazosin is a useful α1 and α2B-adrenoceptor antagonist.

Formula: C₁₉H₂₁N₅O₄

Color and Shape: Neat

Molecular weight: 383.40

Ref: TR-P702333

[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone

CAS: 19216-56-9

Leflunomide is a drug that belongs to the class of pyridones. It is used in the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Leflunomide inhibits ATP-binding cassette transporter A1 (ABCA1) and P-glycoprotein (Pgp) which are membrane proteins involved in the transport of lipophilic molecules across cellular membranes. Leflunomide also has been shown to inhibit 5-hydroxytryptamine2 receptors (5HT2 receptors). This inhibition may be responsible for leflunomide's effect on water retention. Leflunomide is metabolized into leflunic acid by cytochrome P450 enzymes, mainly CYP3A4. The activity of leflunic acid is similar to that of leflunomide.

Formula: C₁₉H₂₁N₅O₄

Purity: Min. 95%

Molecular weight: 383.4 g/mol

Ref: 3D-IA63850

Prazosin

CAS: 19216-56-9

Purity: 98%

Molecular weight: 383.4079895

Ref: 10-F787576