CAS 192329-42-3

Prinomastat

Description:

Prinomastat is a synthetic compound classified as a small molecule inhibitor, primarily known for its role as an angiogenesis inhibitor. It is designed to interfere with the activity of matrix metalloproteinases (MMPs), which are enzymes involved in the breakdown of extracellular matrix components and play a crucial role in tumor growth and metastasis. By inhibiting MMPs, Prinomastat aims to restrict the ability of tumors to invade surrounding tissues and form new blood vessels, thereby potentially limiting cancer progression. The compound has been investigated in various preclinical and clinical studies for its therapeutic potential in treating different types of cancer. In terms of its chemical structure, Prinomastat features a specific arrangement of atoms that contributes to its biological activity, although detailed structural information is typically found in specialized chemical databases. As with many investigational drugs, the safety and efficacy of Prinomastat are evaluated through rigorous clinical trials before it can be approved for general medical use.

Formula: C₁₈H₂₁N₃O₅S₂

InChI: InChI=1/C18H21N3O5S2/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14/h3-10,16,23H,11-12H2,1-2H3,(H,20,22)/t16-/m0/s1

InChI key: InChIKey=YKPYIPVDTNNYCN-INIZCTEOSA-N

SMILES: S(=O)(=O)(N1[C@@H](C(NO)=O)C(C)(C)SCC1)C2=CC=C(OC=3C=CN=CC3)C=C2

Synonyms:

• (3S)-N-Hydroxy-2,2-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylthiomorpholine-3-carboxamide
• (3S)-N-Hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-3-thiomorpholinecarboxamide
• (3S)-N-hydroxy-2,2-dimethyl-4-{[4-(pyridin-4-yloxy)phenyl]sulfonyl}thiomorpholine-3-carboxamide
• (S)-2,2-Dimethyl-N-Hydroxy-4-[4-(4-Pyridyloxy)Phenylsulfonyl]-1,4-Thiazinane-3-Carboxamide
• (S)-2-[(Hydroxyamino)methyl]-5,6-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylmorpholine-3-thione
• 2-[(Hydroxyamino)Methyl]-5,6-Dimethyl-4-(4-Pyridin-4-Yloxyphenyl)Sulfonyl-Morpholine-3-Thione
• 3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (3S)-
• 3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (S)-
• Ag 3340
• Kb-R 9896
• Prinomastat
• AG3340 hydrochloride
• (3S)-N-hydroxy-2,2-dimethyl-4-[4-(pyridin-4-yloxy) benzenesulfonyl]thiomorpholine-3-carboxamide
• Ag3340
• (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride
• AG-3340 hydrochloride
• Prinomastat hydrochloride

3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (3S)-

CAS: 192329-42-3

Formula: C₁₈H₂₁N₃O₅S₂

Purity: 98.0%

Molecular weight: 423.5064

Ref: IN-DA002FUQ

Prinomastat

CAS: 192329-42-3

Prinomastat

Purity: ≥98%

Molecular weight: 423.51g/mol

Ref: 54-BUP01516

Prinomastat

Controlled Product

CAS: 192329-42-3

Formula: C₁₈H₂₁N₃O₅S₂

Color and Shape: Neat

Molecular weight: 423.506

Ref: TR-P715005

Prinomastat

CAS: 192329-42-3

Prinomastat is a small molecule that inhibits the protein MCL-1. It has been shown to inhibit tumor growth in mouse xenograft models of human breast, lung, and prostate cancer. This drug also blocks the expression of matrix metalloproteinases (MMPs), which are enzymes that break down collagen and other extracellular matrix components. Prinomastat inhibits iron homeostasis and induces apoptosis in epithelial cells, suggesting a role for this drug in the treatment of bowel diseases such as Crohn's disease.

Formula: C₁₈H₂₁N₃O₅S₂

Purity: Min. 95%

Molecular weight: 423.51 g/mol

Ref: 3D-SHA32942

Prinomastat

CAS: 192329-42-3

Prinomastat: orally active, crosses blood-brain barrier, inhibits MMP-1/2/3/9, Ki/IC50s: 0.05-0.3/5.0-79 nM, antitumor.

Formula: C₁₈H₂₁N₃O₅S₂

Purity: 99.23%

Color and Shape: Solid

Molecular weight: 423.51

Ref: TM-T12539L