CAS 192441-08-0

Lomeguatrib

Description:

Lomeguatrib, with the CAS number 192441-08-0, is a chemical compound that has garnered attention primarily for its application in the field of medicinal chemistry, particularly as a potential therapeutic agent. It is characterized by its unique molecular structure, which includes specific functional groups that contribute to its biological activity. Lomeguatrib acts as a selective inhibitor of certain enzymes, which can play a crucial role in various biochemical pathways. This selectivity is significant for its potential use in treating conditions such as cancer, where modulation of enzyme activity can influence tumor growth and progression. The compound's pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its efficacy and safety profile in clinical settings. Additionally, ongoing research is focused on understanding its mechanism of action and optimizing its therapeutic potential. As with many experimental compounds, further studies are necessary to fully elucidate its characteristics and applications in medicine.

Formula: C₁₀H₈BrN₅OS

InChI: InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)

InChI key: InChIKey=JUJPKFNFCWJBCX-UHFFFAOYSA-N

SMILES: O(CC1=CC(Br)=CS1)C2=C3C(=NC(N)=N2)N=CN3

Synonyms:

• 1H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
• 2-Amino-6-(4-bromothiophen-2-ylmethoxy)-9H-purine
• 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
• 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine
• 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
• 9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
• PaTrin 2
• Lomeguatrib

9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-

CAS: 192441-08-0

Formula: C₁₀H₈BrN₅OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 326.1724

Ref: IN-DA002FYO

Lomeguatrib

CAS: 192441-08-0

Lomeguatrib

Purity: ≥98%

Molecular weight: 326.17g/mol

Ref: 54-BUP10544

Lomeguatrib

CAS: 192441-08-0

Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .

Formula: C₁₀H₈BrN₅OS

Purity: 99.26% - >99.99%

Color and Shape: Solid

Molecular weight: 326.17

Ref: TM-T2495

Lomeguatrib

CAS: 192441-08-0

Inhibitor and pseudosubstrate of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). It is used as a sensitizer for the treatment of advanced solid tumors, including prostate, colorectal and central nervous system malignancies. Lomeguatrib inhibits the repair mechanism of DNA damage induced by alkylating agents such as temozolomide, and therefore potentiates its anti-cancer effects.

Formula: C₁₀H₈BrN₅OS

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 324.96329

Ref: 3D-FL65065